Bax inserts into the mitochondrial outer membrane by different mechanisms

被引：42

作者：

Cartron, Pierre-Francois ^{[1
,2
]}

Bellot, Gregory ^{[1
,2
]}

Oliver, Lisa ^{[1
,2
]}

Grandier-Vazeille, Xavier ^{[3
]}

Manon, Stephen ^{[3
]}

Vallette, Francois M. ^{[1
,2
]}

机构：

[1] Ctr Rech Cancerol Nantes Angers, INSERM, U 892, IFR 26, F-44035 Nantes 01, France

[2] Univ Nantes, Fac Med, F-44035 Nantes 01, France

[3] Univ Bordeaux, CNRS, UMR 5095, F-33077 Bordeaux, France

来源：

FEBS LETTERS | 2008年 / 582卷 / 20期

关键词：

apoptosis; Bax; mitochondria; TOM; autocatalysis;

D O I：

10.1016/j.febslet.2008.07.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bax insertion into the mitochondrial outer membrane is essential for the implementation of apoptosis. However, little is known about the first stage of Bax integration into the mitochondrial outer membrane. We have recently shown that TOM22, a mitochondrial outer membrane receptor, is important for insertion, although other reports have suggested that only mitochondrial lipids are involved in this process. Here, we show that monomers, but not dimers, of Bax require the presence of TOM22 and TOM40 to integrate into mitochondria. In addition we show that once inserted into the membrane, Bax can act as a receptor for cytosolic Bax. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3045 / 3051

页数：7

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