Decreased regional cerebral metabolic rate for glucose in systemic lupus erythematosus patients with psychiatric symptoms

被引：29

作者：

Komatsu, N

Kodama, K

Yamanouchi, N

Okada, S

Noda, S

Nawata, Y

Takabayashi, K

Iwamoto, I

Saito, Y

Uchida, Y

Ito, H

Yoshikawa, K

Sato, T

机构：

[1] Chiba Univ, Sch Med, Dept Neuropsychiat, Chuo Ku, Chiba 2608677, Japan

[2] Chiba Univ, Sch Med, Dept Internal Med 2, Chiba 2608677, Japan

[3] Chiba Univ, Sch Med, Dept Radiol, Chiba 2608677, Japan

[4] Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Div Radiat Med, Chiba 260, Japan

来源：

EUROPEAN NEUROLOGY | 1999年 / 42卷 / 01期

关键词：

systemic lupus erythematosus; psychiatric symptom; positron emission tomography; regional cerebral metabolic rate for glucose attentional deficits;

D O I：

10.1159/000008067

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To determine brain functional abnormality in systemic lupus erythematosus (SLE) patients with psychiatric symptoms, we evaluated 12 active SLE patients with or without psychiatric symptoms by means of [F-18]2-fluoro-2-deoxy-D-glucose positron emission tomography (PET), magnetic resonance imaging and neuropsychological testing. Patients with psychiatric symptoms showed significantly poorer performance in tests which subserved attentional function. The PET study revealed that the psychiatric patients had significantly decreased regional cerebral metabolic rates for glucose in the prefrontal, inferior parietal and anterior cingulate regions. Prefrontal, inferior parietal and anterior cingulate dysfunction may be related to attentional deficits that are involved in various psychiatric symptoms in SLE. PET is an invaluable tool to reveal such brain functional abnormality seen in SLE patients with psychiatric symptoms.

引用

页码：41 / 48

页数：8

共 37 条

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