CARD games between virus and host get a new player

被引：98

作者：

Johnson, CL ^{[1
]}

Gale, M ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX 75390 USA

来源：

TRENDS IN IMMUNOLOGY | 2006年 / 27卷 / 01期

关键词：

D O I：

10.1016/j.it.2005.11.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A growing family of cellular proteins encoding the caspase activation and recruitment domain (CARD) has a crucial role in immunity by sensing virus infection and signaling antiviral immune defenses. Four independent studies have identified a novel CARD-containing protein, variously called IPS-1, MAVS, VISA and Cardif, which is an essential signaling adaptor of the host defense mediating CARD-CARD interactions with retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDAS), sensors of virus infection. Disruption of this novel signaling pathway by hepatitis C virus (HCV) might provide a foundation for viral persistence.

引用

页码：1 / 4

页数：4

共 22 条

[1] De Francesco R, 2000, CURR TOP MICROBIOL, V242, P149
[2] Regulation of IL-1β generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins
Druilhe, A
Srinivasula, SM
Razmara, M
Ahmad, M
Alnemri, ES
[J]. CELL DEATH AND DIFFERENTIATION, 2001, 8 (06) : 649 - 657
[3] IKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, KA
McWhirter, SM
Faia, KL
Rowe, DC
Latz, E
Golenbock, DT
Coyle, AJ
Liao, SM
Maniatis, T
[J]. NATURE IMMUNOLOGY, 2003, 4 (05) : 491 - 496
[4] Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling
Foy, E
Li, K
Sumpter, R
Loo, YM
Johnson, CL
Wang, CF
Fish, PM
Yoneyama, M
Fujita, T
Lemon, SM
Gale, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (08) : 2986 - 2991
[5] Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease
Foy, E
Li, K
Wang, CF
Sumpter, R
Ikeda, M
Lemon, SM
Gale, M
[J]. SCIENCE, 2003, 300 (5622) : 1145 - 1148
[6] Evasion of intracellular host defence by hepatitis C virus
Gale, M
Foy, EM
[J]. NATURE, 2005, 436 (7053) : 939 - 945
[7] mda-5:: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
Kang, DC
Gopalkrishnan, RV
Wu, QP
Jankowsky, E
Pyle, AM
Fisher, PB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) : 637 - 642
[8] Viruses and interferon: A fight for supremacy
Katze, MG
He, YP
Gale, M
[J]. NATURE REVIEWS IMMUNOLOGY, 2002, 2 (09) : 675 - 687
[9] IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Kawai, T
Takahashi, K
Sato, S
Coban, C
Kumar, H
Kato, H
Ishii, KJ
Takeuchi, O
Akira, S
[J]. NATURE IMMUNOLOGY, 2005, 6 (10) : 981 - 988
[10] Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
Li, K
Foy, E
Ferreon, JC
Nakamura, M
Ferreon, ACM
Ikeda, M
Ray, SC
Gale, M
Lemon, SM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (08) : 2992 - 2997

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