Epistasis and the release of genetic variation during long-term selection

被引：214

作者：

Carlborg, Ö

Jacobsson, L

Åhgren, P

Siegel, P

Andersson, L

机构：

[1] Uppsala Univ, Linnaeus Ctr Bioinformat, SE-75124 Uppsala, Sweden

[2] Swedish Univ Agr Sci, Dept Anim Breeding & Genet, SE-75124 Uppsala, Sweden

[3] Swedish Univ Agr Sci, Dept Med Biochem & Microbiol, SE-75124 Uppsala, Sweden

[4] Virginia Polytech Inst & State Univ, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA

来源：

NATURE GENETICS | 2006年 / 38卷 / 04期

关键词：

D O I：

10.1038/ng1761

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It is an enigma how long-term selection in model organisms and agricultural species can lead to marked phenotypic changes without exhausting genetic variation for the selected trait. Here, we show that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci. The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model.

引用

页码：418 / 420

页数：3

共 15 条

[1] Epistasis:: too often neglected in complex trait studies? [J].