Utility of 18F-Fluoride PET/CT and 18F-FDG PET/CT in the Detection of Bony Metastases in Heightened-Risk Head and Neck Cancer Patients

被引：14

作者：

Chan, Sheng-Chieh ^{[1
,2
,3
]}

Wang, Hung-Ming ^{[4
]}

Ng, Shu-Hang ^{[5
]}

Hsu, Cheng-Lung ^{[4
]}

Lin, Yu-Jr ^{[6
]}

Lin, Chien-Yu ^{[7
,8
]}

Liao, Chun-Ta ^{[9
]}

Yen, Tzu-Chen ^{[2
,3
]}

机构：

[1] Chang Gung Mem Hosp, Dept Nucl Med, Keelong, Taiwan

[2] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Mol Imaging Ctr, Tao Yuan, Taiwan

[3] Chang Gung Univ, Dept Nucl Med, Coll Med, Chang Gung Mem Hosp, Tao Yuan, Taiwan

[4] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Div Hematol Oncol,Dept Internal Med, Tao Yuan, Taiwan

[5] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Diagnost Radiol, Tao Yuan, Taiwan

[6] Chang Gung Mem Hosp, Biostat Ctr Clin Res, Tao Yuan, Taiwan

[7] Chang Gung Univ, Grad Inst Clin Med Sci, Tao Yuan, Taiwan

[8] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Radiat Oncol, Tao Yuan, Taiwan

[9] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Otorhinolaryngol, Tao Yuan, Taiwan

来源：

JOURNAL OF NUCLEAR MEDICINE | 2012年 / 53卷 / 11期

关键词：

F-18-FDG; F-18-fluoride; PET; head and neck cancer; bony metastases; diagnosis; BREAST-CANCER; SCINTIGRAPHY; CARCINOMA; DISEASE; LESIONS; CT;

D O I：

10.2967/jnumed.112.104893

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

This study compared the diagnostic accuracy of F-18-FDG PET/CT with that of F-18-fluoride PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients. Methods: The study participants underwent F-18-FDG PET/CT and F-18-fluoride PET/CT within 2 wk of each another. Results: A total of 98 bony metastases were found in 18 of our 80 patients. F-18-fluoride PET/CT and F-18-FDG PET/CT showed similar lesion-based sensitivity (69.4% vs. 57.1%, P = 0.126) and areas under the curve (0.7561 vs. 0.7959, P = 0.149). Their combined interpretation demonstrated a significantly greater sensitivity and areas under the curve than that obtained with either modality alone (P < 0.001) in lesion-based analysis but not in patient-based analysis, with a treatment strategy change in 2 patients. Conclusion: F-18-fluoride PET/CT is a feasible modality for detecting bony metastases in patients with head and neck cancers, with similar sensitivity to F-18-FDG PET/CT. Their combined use may not be justifiable.

引用

页码：1730 / 1735

页数：6

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