Common 5p15.33 and 6p21.33 variants influence lung cancer risk

被引：469

作者：

Wang, Yufei ^{[1
]}

Broderick, Peter ^{[1
]}

Webb, Emily ^{[1
]}

Wu, Xifeng ^{[2
]}

Vijayakrishnan, Jayaram ^{[1
]}

Matakidou, Athena ^{[1
]}

Qureshi, Mobshra ^{[1
]}

Dong, Qiong ^{[2
]}

Gu, Xiangjun ^{[2
]}

Chen, Wei Vivien ^{[2
]}

Spitz, Margaret R. ^{[2
]}

Eisen, Timothy ^{[3
]}

Amos, Christopher I. ^{[2
]}

Houlston, Richard S. ^{[1
]}

机构：

[1] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England

[2] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[3] Univ Cambridge, Dept Oncol, Cambridge CB2 2RE, England

来源：

NATURE GENETICS | 2008年 / 40卷 / 12期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/ng.273

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 x 10(-12)), confirming recent observations. Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; P-combined 4.97 x 10(-10)) and 5p15.33 (rs401681, CLPTM1L; P-combined 7.90 x 10(-9)).

引用

页码：1407 / 1409

页数：3

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