Dietary and adipose tissue gamma-tocopherol and risk of myocardial infarction

被引:16
作者
El-Sohemy, A
Baylin, A
Spiegelman, D
Ascherio, A
Campos, H
机构
[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[4] Univ Costa Rica, Inst Invest Salud, San Pedro, Costa Rica
关键词
adipose tissue; biomarkers; coronary heart disease; diet; myocardial infarction; nutrition; gamma; tucopherol; vitamin E;
D O I
10.1097/00001648-200203000-00018
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background. Gamma-tocopherol, the most abundant form of dietary vitamin E, may lower the risk of coronary heart disease. Methods. We investigated whether dietary and adipose tissue gamma-tocopherol are associated with myocardial infarction (MI) in 475 survivors of a first MI and 479 controls from a population-based study carried out between 1994 and 1998 in Costa Rica. Dietary intake was assessed with a validated food-frequency questionnaire and an adipose tissue sample. Conditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI). Results. Subjects in the highest quintile of dietary gamma-tocopherol had a lower risk of MI compared with those in the lowest quintile (OR = 0.76; 95% CI = 0.50-1.17, P = 0.02 for trend). This trend was no longer statistically substantial in multivariate analysis (P = 0.44). A weak association was found for adipose tissue gamma-tocopherol in univariate (OR = 1.46; 95% CI = 0.94-2.27) and multivariate (OR = 1.31; 95% CI = 0.62-2.76) models. A substantial inverse association with MI was found for total dietary vitamin E whether supplement users were included or excluded (P = 0.01 and 0.05 for trend, respectively). Conclusion. These data suggest that gamma-tocopherol does not protect against nonfatal MI.
引用
收藏
页码:216 / 223
页数:8
相关论文
共 44 条
[1]   RAPID SAMPLING AND LONG-TERM STORAGE OF SUBCUTANEOUS ADIPOSE-TISSUE BIOPSIES FOR DETERMINATION OF FATTY-ACID COMPOSITION [J].
BEYNEN, AC ;
KATAN, MB .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1985, 42 (02) :317-322
[2]   SOURCES AND CONSUMPTION OF ANTIOXIDANTS IN THE DIET [J].
BIERI, JG .
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1984, 61 (12) :1917-1918
[3]   GAMMA-TOCOPHEROL - METABOLISM, BIOLOGICAL-ACTIVITY AND SIGNIFICANCE IN HUMAN VITAMIN-E NUTRITION [J].
BIERI, JG ;
EVARTS, RP .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1974, 27 (09) :980-986
[4]   ABSORPTION, TRANSPORT AND DISTRIBUTION OF VITAMIN-E [J].
BJORNEBOE, A ;
BJORNEBOE, GEA ;
DREVON, CA .
JOURNAL OF NUTRITION, 1990, 120 (03) :233-242
[5]   Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial [J].
Boaz, M ;
Smetana, S ;
Weinstein, T ;
Matas, Z ;
Gafter, U ;
Iaina, A ;
Knecht, A ;
Weissgarten, Y ;
Brunner, D ;
Fainaru, M ;
Green, MS .
LANCET, 2000, 356 (9237) :1213-1218
[6]   Siesta and the risk of coronary heart disease: results from a population-based, case-control study in Costa Rica [J].
Campos, H ;
Siles, X .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2000, 29 (03) :429-437
[7]   gamma-Tocopherol traps mutagenic electrophiles such as NOx and complements alpha-tocopherol: Physiological implications [J].
Christen, S ;
Woodall, AA ;
Shigenaga, MK ;
SouthwellKeely, PT ;
Duncan, MW ;
Ames, BN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (07) :3217-3222
[8]   Graded dietary levels of RRR-gamma-tocopherol induce a marked increase in the concentrations of alpha- and gamma-tocopherol in nervous tissues, heart, liver and muscle of vitamin-E-deficient rats [J].
Clement, M ;
Bourre, JM .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1997, 1334 (2-3) :173-181
[9]   GAMMA-TOCOPHEROL DETOXIFICATION OF NITROGEN-DIOXIDE - SUPERIORITY TO ALPHA-TOCOPHEROL [J].
COONEY, RV ;
FRANKE, AA ;
HARWOOD, PJ ;
HATCHPIGOTT, V ;
CUSTER, LJ ;
MORDAN, LJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) :1771-1775
[10]  
El-Sohemy A, 2001, AM J CLIN NUTR, V74, P356