Under arrest in mitosis: Cdc20 dies twice

被引：5

作者：

Fry, Andrew M. ^{[1
]}

Yamano, Hiroyuki ^{[2
]}

机构：

[1] Univ Leicester, Dept Biochem, Leicester LE1 9HN, Leics, England

[2] Marie Curie Res Inst, Oxted RH8 0TL, Surrey, England

来源：

NATURE CELL BIOLOGY | 2008年 / 10卷 / 12期

关键词：

D O I：

10.1038/ncb1208-1385

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.

引用

页码：1385 / 1387

页数：3

共 15 条

[1] Mad3p, a pseudosubstrate inhibitor of APCCdc20 in the spindle assembly checkpoint [J].

Burton, Janet L. ;

Solomon, Mark J. .

GENES & DEVELOPMENT, 2007, 21 (06) :655-667

[2] Spindle checkpoint function requires Mad2-dependent Cdc20 binding to the Mad3 homology domain of BubR1 [J].

Davenport, James ;

Harris, Loleta D. ;

Goorha, Rakesh .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (10) :1831-1842

[3] Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex [J].

Fang, GW .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (03) :755-766

[4] MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p [J].

Hardwick, KC ;

Johnston, RC ;

Smith, DL ;

Murray, AW .

JOURNAL OF CELL BIOLOGY, 2000, 148 (05) :871-882

[5] Mad3 KEN Boxes Mediate both Cdc20 and Mad3 Turnover, and Are Critical for the Spindle Checkpoint [J].

King, Emma M. J. ;

van der Sar, Sjaak J. A. ;

Hardwick, Kevin G. .

PLOS ONE, 2007, 2 (04)

[6] The spindle checkpoint: Structural insights into dynamic signalling [J].

Musacchio, A ;

Hardwick, KG .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (10) :731-741

[7] The spindle-assembly checkpoint in space and time [J].

Musacchio, Andrea ;

Salmon, Edward D. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (05) :379-393

[8] The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction [J].

Nilsson, Jakob ;

Yekezare, Mona ;

Minshull, Jeremy ;

Pines, Jonathon .

NATURE CELL BIOLOGY, 2008, 10 (12) :1411-U74

[9] Spindle checkpoint regulates Cdc20p stability in Saccharomyces cerevisiae [J].

Pan, J ;

Chen, RH .

GENES & DEVELOPMENT, 2004, 18 (12) :1439-1451

[10] The anaphase promoting complex/cyclosome: a machine designed to destroy [J].

Peters, Jan-Michael .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (09) :644-656

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