The effect of calorie restriction on acute ethanol-induced oxidative and nitrosative liver injury in rats

被引：16

作者：

Mladenovic, Dusan ^{[1
]}

Ninkovic, Milica ^{[2
]}

Aleksic, Vuk ^{[1
]}

Sljivancanin, Tamara ^{[3
]}

Vucevic, Danijela ^{[1
]}

Todorovic, Vera ^{[4
]}

Stankovic, Milena ^{[1
]}

Stanojlovic, Olivera ^{[5
]}

Radosavljevic, Tatjana ^{[1
]}

机构：

[1] Univ Belgrade, Fac Med, Inst Pathophysiol Ljubodrag Buba Mihailovic, Belgrade, Serbia

[2] Mil Med Acad, Inst Med Res, Belgrade 11002, Serbia

[3] Univ Belgrade, Fac Med, Clin Gynecol & Obstet Narodni Front, Belgrade, Serbia

[4] Univ Business Econ, Fac Dent, Novi Sad, Serbia

[5] Univ Belgrade, Fac Med, Inst Med Physiol Richard Burian, Belgrade, Serbia

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2013年 / 36卷 / 02期

关键词：

Calorie restriction; Liver; Oxidative stress; Ethanol; Rats; LIFE-SPAN; STRESS; MITOCHONDRIA; RETARDATION; EXTENSION; DEATH;

D O I：

10.1016/j.etap.2013.04.002

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

The aim of our study was to examine the effect of calorie restriction (CR) on oxidative and nitrosative liver injury in rats, induced by acute ethanol intoxication. Male Wistar rats were divided into groups: (1) control; (2) calorie-restricted groups with intake of 60-70% (CR60-70) and 40-50% of daily energy needs (CR40-50); (3) ethanol-treated group (E); (4) calorie-restricted, ethanol-treated groups (E + CR60-70 and E + CR40-50). Ethanol was administered in 5 doses of 2 g/kg every 12 h, and duration of CR was 5 weeks before ethanol treatment. Malondialdehyde and nitrite and nitrate level were significantly lower in E + CR60-70 and higher in E + CR40-50 vs. E group. Liver reduced glutathione content and activity of both superoxide dismutase izoenzymes were significantly higher in E + CR60-70 and lower in E + CR40-50 vs. E group. Oxidative stress may be a potential mechanism of hormetic effects of CR on acute ethanol-induced liver injury. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：296 / 302

页数：7

共 35 条

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