R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

被引：61

作者：

Sleeman, Katrina ^{[1
]}

Guo, Zhu ^{[1
]}

Barnes, John ^{[1
]}

Shaw, Michael ^{[1
]}

Stevens, James ^{[1
]}

Gubareva, Larisa V. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA 30333 USA

来源：

EMERGING INFECTIOUS DISEASES | 2013年 / 19卷 / 09期

关键词：

NEURAMINIDASE ACTIVE-SITE; RESISTANCE; SENSITIVITY; INHIBITORS; MUTATIONS;

D O I：

10.3201/eid1909.130724

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitness in cell culture. Monitoring emergence of R292K-carrying viruses using a pH-modified neuraminidase inhibition assay should be considered.

引用

页码：1521 / 1524

页数：4

共 15 条

[1]

[Anonymous], 2012, Wkly Epidemiol Rec, V87, P369

[2] Influenza virus carrying neuraminidase with reduced sensitivity to oseltamivir carboxylate has altered properties in vitro and is compromised for infectivity and replicative ability in vivo [J].

Carr, J ;

Ives, J ;

Kelly, L ;

Lambkin, R ;

Oxford, J ;

Mendel, D ;

Tai, L ;

Roberts, N .

ANTIVIRAL RESEARCH, 2002, 54 (02) :79-88

[3]

Centers for Disease Control and Prevention, 2013, MMWR-MORBID MORTAL W, V62, P1

[4] Pyrosequencing as a tool to detect molecular markers of resistance to neuraminidase inhibitors in seasonal influenza A viruses [J].

Deyde, Varough M. ;

Okomo-Adhiambo, Margaret ;

Sheu, Tiffany G. ;

Wallis, Teresa R. ;

Fry, Alicia ;

Dharan, Nila ;

Klimov, Alexander I. ;

Gubareva, Larisa V. .

ANTIVIRAL RESEARCH, 2009, 81 (01) :16-24

[5] Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus [J].

Gao, Rongbao ;

Cao, Bin ;

Hu, Yunwen ;

Feng, Zijian ;

Wang, Dayan ;

Hu, Wanfu ;

Chen, Jian ;

Jie, Zhijun ;

Qiu, Haibo ;

Xu, Ke ;

Xu, Xuewei ;

Lu, Hongzhou ;

Zhu, Wenfei ;

Gao, Zhancheng ;

Xiang, Nijuan ;

Shen, Yinzhong ;

He, Zebao ;

Gu, Yong ;

Zhang, Zhiyong ;

Yang, Yi ;

Zhao, Xiang ;

Zhou, Lei ;

Li, Xiaodan ;

Zou, Shumei ;

Zhang, Ye ;

Li, Xiyan ;

Yang, Lei ;

Guo, Junfeng ;

Dong, Jie ;

Li, Qun ;

Dong, Libo ;

Zhu, Yun ;

Bai, Tian ;

Wang, Shiwen ;

Hao, Pei ;

Yang, Weizhong ;

Zhang, Yanping ;

Han, Jun ;

Yu, Hongjie ;

Li, Dexin ;

Gao, George F. ;

Wu, Guizhen ;

Wang, Yu ;

Yuan, Zhenghong ;

Shu, Yuelong .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (20) :1888-1897

[6] Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en [J].

Gubareva, LV ;

Robinson, MJ ;

Bethell, RC ;

Webster, RG .

JOURNAL OF VIROLOGY, 1997, 71 (05) :3385-3390

[7] Influenza virus carrying an R292K mutation in the neuraminidase gene is an transmitted in ferrets [J].

Herlocher, ML ;

Carr, J ;

Ives, J ;

Elias, S ;

Truscon, R ;

Roberts, N ;

Monto, AS .

ANTIVIRAL RESEARCH, 2002, 54 (02) :99-111

[8] Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance [J].

Hu, Yunwen ;

Lu, Shuihua ;

Song, Zhigang ;

Wang, Wei ;

Hao, Pei ;

Li, Jianhua ;

Zhang, Xiaonan ;

Yen, Hui-Ling ;

Shi, Bisheng ;

Li, Tao ;

Guan, Wencai ;

Xu, Lei ;

Liu, Yi ;

Wang, Sen ;

Zhang, Xiaoling ;

Tian, Di ;

Zhu, Zhaoqin ;

He, Jing ;

Huang, Kai ;

Chen, Huijie ;

Zheng, Lulu ;

Li, Xuan ;

Ping, Jie ;

Kang, Bin ;

Xi, Xiuhong ;

Zha, Lijun ;

Li, Yixue ;

Zhang, Zhiyong ;

Peiris, Malik ;

Yuan, Zhenghong .

LANCET, 2013, 381 (9885) :2273-2279

[9] Assessing the Viral Fitness of Oseltamivir-Resistant Influenza Viruses in Ferrets, Using a Competitive-Mixtures Model [J].

Hurt, Aeron C. ;

Nor'e, Siti Sarah ;

McCaw, James M. ;

Fryer, Helen R. ;

Mosse, Jennifer ;

McLean, Angela R. ;

Barr, Ian G. .

JOURNAL OF VIROLOGY, 2010, 84 (18) :9427-9438

[10] Epidemiology of Human Infections with Avian Influenza A(H7N9) Virus in China [J].

Li, Qun ;

Zhou, Lei ;

Zhou, Minghao ;

Chen, Zhiping ;

Li, Furong ;

Wu, Huanyu ;

Xiang, Nijuan ;

Chen, Enfu ;

Tang, Fenyang ;

Wang, Dayan ;

Meng, Ling ;

Hong, Zhiheng ;

Tu, Wenxiao ;

Cao, Yang ;

Li, Leilei ;

Ding, Fan ;

Liu, Bo ;

Wang, Mei ;

Xie, Rongheng ;

Gao, Rongbao ;

Li, Xiaodan ;

Bai, Tian ;

Zou, Shumei ;

He, Jun ;

Hu, Jiayu ;

Xu, Yangting ;

Chai, Chengliang ;

Wang, Shiwen ;

Gao, Yongjun ;

Jin, Lianmei ;

Zhang, Yanping ;

Luo, Huiming ;

Yu, Hongjie ;

He, Jianfeng ;

Li, Qi ;

Wang, Xianjun ;

Gao, Lidong ;

Pang, Xinghuo ;

Liu, Guohua ;

Yan, Yansheng ;

Yuan, Hui ;

Shu, Yuelong ;

Yang, Weizhong ;

Wang, Yu ;

Wu, Fan ;

Uyeki, Timothy M. ;

Feng, Zijian .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (06) :520-532

← 1 2 →