Genetic aberrations in soft tissue leiomyosarcoma

被引：63

作者：

Yang, Jilong ^{[2
]}

Du, Xiaoling ^{[3
]}

Chen, Kexin ^{[4
]}

Ylipaeae, Antti ^{[1
,9
]}

Lazar, Alexander J. F. ^{[1
,8
]}

Trent, Jonathan ^{[5
,8
]}

Lev, Dina ^{[7
,8
]}

Pollock, Raphael ^{[6
,8
]}

Hao, Xishan ^{[2
,3
,4
]}

Hunt, Kelly ^{[6
]}

Zhang, Wei ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA

[2] Tianjin Med Univ, Dept Bone & Soft Tissue Tumor, Tianjin Canc Hosp & Inst, Tianjin 30060, Peoples R China

[3] Tianjin Med Univ, Dept Diagnost, Tianjin 30060, Peoples R China

[4] Tianjin Med Univ, Dept Epidemiol & Biostat, Tianjin Canc Hosp & Inst, Tianjin 30060, Peoples R China

[5] Univ Texas MD Anderson Canc Ctr, Dept Sarcoma Med Oncol, Houston, TX 77030 USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA

[7] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

[8] Univ Texas MD Anderson Canc Ctr, Sarcoma Res Ctr, Houston, TX 77030 USA

[9] Tampere Univ Technol, Dept Signal Proc, FIN-33101 Tampere, Finland

来源：

CANCER LETTERS | 2009年 / 275卷 / 01期

关键词：

Leiomyosarcoma; Genetic alteration; Array CGH; Karyotype; Sarcoma; COMPARATIVE GENOMIC HYBRIDIZATION; GASTROINTESTINAL STROMAL TUMORS; DNA COPY NUMBER; CHAMP STUDY-GROUP; UTERINE LEIOMYOSARCOMA; PROMOTER METHYLATION; POOR-PROGNOSIS; HUMAN SARCOMAS; EXPRESSION; AMPLIFICATION;

D O I：

10.1016/j.canlet.2008.06.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Leiomyosarcoma is a malignant mesenchymal tumor composed of cells showing smooth muscle differentiation. This tumor usually occurs in middle-aged or older adults, and forms a significant percentage of retroperitoneal, vascular, extremity, and uterine sarcomas. Leiomyosarcomas are most often associated with complex karyotypes with numerous chromosomal gains and losses. Some of these cytogenetic and molecular genetic aberrations correlate with histopathologic features and clinical outcomes. Identification of genetic alterations with specific identification of oncogenes and tumor suppressor genes may lead to additional insights into the tumorigenesis of leiomyosarcoma and the opportunity to confer the benefits of targeted therapy. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 8

页数：8

共 47 条

[1] Gene expression profiling of human sarcomas: Insights into sarcoma biology [J].

Baird, K ;

Davis, S ;

Antonescu, CR ;

Harper, UL ;

Walker, RL ;

Chen, YD ;

Glatfelter, AA ;

Duray, PH ;

Meltzer, PS .

CANCER RESEARCH, 2005, 65 (20) :9226-9235

[2] The death-associated protein kinases: Structure, function, and beyond [J].

Bialik, Shani ;

Kimchi, Adi .

ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 :189-210

[3] Array comparative genomic hybridization analysis of uterine leiomyosarcoma [J].

Cho, YL ;

Bae, S ;

Koo, MS ;

Kim, KM ;

Chun, HJ ;

Kim, CK ;

Ro, DY ;

Kim, JH ;

Lee, CH ;

Kim, YW ;

Ahn, WS .

GYNECOLOGIC ONCOLOGY, 2005, 99 (03) :545-551

[4]

Coindre JM, 2001, CANCER-AM CANCER SOC, V91, P1914, DOI 10.1002/1097-0142(20010515)91:10<1914::AID-CNCR1214>3.0.CO

[5]

2-3

[6] Molecular pathology in sarcomas [J].

de Alava, E. .

CLINICAL & TRANSLATIONAL ONCOLOGY, 2007, 9 (03) :130-144

[7] Leiomyosarcomas and most malignant fibrous histiocytomas share very similar comparative genomic hybridization imbalances:: An analysis of a series of 27 leiomyosarcomas [J].

Derré, J ;

Lagacé, R ;

Nicolas, A ;

Mairal, A ;

Chibon, F ;

Coindre, JM ;

Terrier, P ;

Sastre, X ;

Aurias, A .

LABORATORY INVESTIGATION, 2001, 81 (02) :211-215

[8] DNA copy number changes in development and progression in leiomyosarcomas of soft tissues [J].

El-Rifai, W ;

Sarlomo-Rikala, M ;

Knuutila, S ;

Miettinen, M .

AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (03) :985-990

[9]

Evans H.S., 2002, WHO CLASSIFICATION T, P131

[10]

Fletcher CDM., 2002, WHO CLASSIFICATION T, P12

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