Hemophagocytic Lymphohistiocytosis in a Rheumatoid Arthritis Patient Treated with Infliximab

被引：18

作者：

Oda, Yuzo ^{[1
]}

Urushidani, Yoshinori ^{[1
]}

Ooi, Shinji ^{[1
]}

Endoh, Akira ^{[1
]}

Nakamura, Rika ^{[1
]}

Adachi, Koji ^{[1
]}

Fukushima, Hiroko ^{[2
]}

机构：

[1] Matsue Red Cross Hosp, Div Hematol Clin Immunol & Nephrol, Matsue, Shimane, Japan

[2] Matsue Citizens Hosp, Div Orthopaed Surg, Matsue, Shimane, Japan

来源：

INTERNAL MEDICINE | 2012年 / 51卷 / 06期

关键词：

hemophagocytic lymphohistiocytosis; Escherichia coli; infliximab; rheumatoid arthritis; bacterial infection; MACROPHAGE ACTIVATION SYNDROME; ETANERCEPT; CHILDREN;

D O I：

10.2169/internalmedicine.51.5687

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Hemophagocytic lymphohistiocytosis (HLH) is a rare condition with high mortality. We report a case of a 74-year-old woman with rheumatoid arthritis who developed HLH secondary to pyelonephritis due to Escherichia coli infection following infliximab treatment. Bone marrow aspiration showed proliferation of histiocytes with hemophagocytosis. The patient died despite treatment with intravenous antibiotics intravenous methylprednisolone and intravenous immunoglobulin. Cytokine levels were measured and are discussed.

引用

页码：655 / 657

页数：3

共 26 条

[1]

Haemophagocytic syndrome in a rheumatoid arthritis patient treated with infliximab [J].

Aouba, A ;

De Bandt, M ;

Aslangul, E ;

Atkhen, N ;

Patri, B .

RHEUMATOLOGY, 2003, 42 (06) :800-U3

[2]

Asci G, 2006, J NEPHROL, V19, P322

[3]

Chang KH, 2003, J FORMOS MED ASSOC, V105, P756

[4]

DINARELLO CA, 1993, NEW ENGL J MED, V328, P106

[5]

Severe bacteria-associated hemophagocytic lymphohistiocytosis in an extremely premature infant [J].

Edner, Josefine ;

Rudd, Eva ;

Zheng, Chengyun ;

Dahlander, Andreas ;

Eksborg, Staffan ;

Schneider, E. Marion ;

Edner, Ann ;

Henter, Jan-Inge .

ACTA PAEDIATRICA, 2007, 96 (11) :1703-1706

[6]

Hemophagocytosis associated with an Escherichia coli sepsis:: a case report [J].

El Khoury, N ;

Lassoued, K ;

Pellé, G ;

Foucher, A ;

Costa, MA ;

Rondeau, E ;

Sraer, JD .

REVUE DE MEDECINE INTERNE, 2003, 24 (10) :688-691

[7]

Reactive haemophagocytic syndrome: A probably underestimated cause of thrombocytopenia in ICU patients [J].

Francois, B ;

Trimoreau, F ;

Vignon, P ;

Verger, G ;

Gastinne, H .

ANNALES FRANCAISES D ANESTHESIE ET DE REANIMATION, 1995, 14 (06) :514-516

[8]

HARA T, 1989, Acta Paediatrica Japonica, V31, P335

[9]

HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis [J].

Henter, Jan-Inge ;

Horne, AnnaCarin ;

Arico, Maurizio ;

Egeler, R. Maarten ;

Filipovich, Alexandra H. ;

Imashuku, Shinsaku ;

Ladisch, Stephan ;

McClain, Ken ;

Webb, David ;

Winiarski, Jacek ;

Janka, Gritta .

PEDIATRIC BLOOD & CANCER, 2007, 48 (02) :124-131

[10]

Success with infliximab in treating refractory hemophagocytic lymphohistiocytosis [J].

Henzan, T ;

Nagafuji, K ;

Tsukamoto, H ;

Miyamoto, T ;

Gondo, H ;

Imashuku, S ;

Harada, M .

AMERICAN JOURNAL OF HEMATOLOGY, 2006, 81 (01) :59-61

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