Structure and function of IRF-7

被引：97

作者：

Zhang, LW

Pagano, JS

机构：

[1] Univ Nebraska, UNL Biol Sci, Nebraska Ctr Virol, Lincoln, NE 68588 USA

[2] Univ N Carolina, Dept Med, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2002年 / 22卷 / 01期

关键词：

D O I：

10.1089/107999002753452700

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interferon (IFN) regulatory factors (IRF) are a family of transcription factors with multiple functions. IRF-7 was initially cloned within the biologic context of Epstein-Barr virus (EBV) latency and discovered to have an intimate relation with the EBV primary oncogenic protein, latent membrane protein-1 (LMP-1). EBV regulates and uses IRF-7 as a secondary mediator for several target genes involved in latency and immune regulation. Other than its functions in EBV latency, IRF-7 has been identified as one of the major players in virally induced IFN production that is central to innate immunity. Thus, IRF-7 plays important roles in a variety of biologic systems.

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页码：95 / 101

页数：7

相关论文

共 58 条

[1]

[Anonymous], 1996, Fields virology

[2] Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes [J].

Au, WC ;

Moore, PA ;

LaFleur, DW ;

Tombal, B ;

Pitha, PM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (44) :29210-29217

[3] Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3 [J].

Au, WC ;

Yeow, WS ;

Pitha, PM .

VIROLOGY, 2001, 280 (02) :273-282

[4] JAK-STAT PATHWAYS AND TRANSCRIPTIONAL ACTIVATION IN RESPONSE TO IFNS AND OTHER EXTRACELLULAR SIGNALING PROTEINS [J].

DARNELL, JE ;

KERR, IM ;

STARK, GR .

SCIENCE, 1994, 264 (5164) :1415-1421

[5] AN INTERFERON GAMMA-REGULATED PROTEIN THAT BINDS THE INTERFERON-INDUCIBLE ENHANCER ELEMENT OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I GENES [J].

DRIGGERS, PH ;

ENNIST, DL ;

GLEASON, SL ;

MAK, WH ;

MARKS, MS ;

LEVI, BZ ;

FLANAGAN, JR ;

APPELLA, E ;

OZATO, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (10) :3743-3747

[6] THE RETINOBLASTOMA PROTEIN ASSOCIATES WITH THE PROTEIN PHOSPHATASE TYPE-1 CATALYTIC SUBUNIT [J].

DURFEE, T ;

BECHERER, K ;

CHEN, PL ;

YEH, SH ;

YANG, YZ ;

KILBURN, AE ;

LEE, WH ;

ELLEDGE, SJ .

GENES & DEVELOPMENT, 1993, 7 (04) :555-569

[7] Structure of IRF-1 with bound DNA reveals determinants of interferon regulation [J].

Escalante, CR ;

Yie, JM ;

Thanos, D ;

Aggarwal, AK .

NATURE, 1998, 391 (6662) :103-106

[8] Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene [J].

Fries, KL ;

Miller, WE ;

RaabTraub, N .

JOURNAL OF VIROLOGY, 1996, 70 (12) :8653-8659

[9] KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway [J].

Gao, SJ ;

Boshoff, C ;

Jayachandra, S ;

Weiss, RA ;

Chang, Y ;

Moore, PS .

ONCOGENE, 1997, 15 (16) :1979-1985

[10] Regulation of RANTES chemokine gene expression requires cooperativity between NF-κB and IFN-regulatory factor transcription factors [J].

Génin, P ;

Algarté, M ;

Roof, P ;

Lin, RT ;

Hiscott, J .

JOURNAL OF IMMUNOLOGY, 2000, 164 (10) :5352-5361

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