Cutting edge: Inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis

被引：51

作者：

Greenwald, RJ

McAdam, AJ

Van der Woude, D

Satoskar, AR

Sharpe, AH

机构：

[1] Brigham & Womens Hosp, Div Immunol Res, Dept Pathol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

[3] Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA

[4] Ohio State Univ, Dept Microbiol, Columbus, OH 43210 USA

来源：

JOURNAL OF IMMUNOLOGY | 2002年 / 168卷 / 03期

关键词：

D O I：

10.4049/jimmunol.168.3.991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The CD28 family member inducible costimulator protein (ICOS) has an important role in T cell differentiation and Ig class switching. To investigate the role of ICOS in vivo, ICOS-/- mice were infected s.c. with Leishmania mexicana. While wild-type mice developed large, cutaneous lesions, the growth of lesions and tissue histopathology was significantly delayed in lCOS(-/-) mice. ICOS-/- mice exhibited marked decreases in both Th1 and Th2 cytokine production and profound defects in L. mexicana-specific Ig isotype class switching to IgG1 and IgG2a and reduced total IgE levels. Our findings indicate that ICOS is a key regulator of both Th1 and Th2 responses and has a role in controlling cutaneous L. mexicana infection.

引用

收藏

页码：991 / 995

页数：5

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