Noncoding RNA control of the making and breaking of sugars

被引:67
作者
Goerke, Boris [2 ]
Vogel, Joerg [1 ]
机构
[1] Max Planck Inst Infect Biol, RNA Biol Grp, D-10117 Berlin, Germany
[2] Univ Gottingen, Dept Gen Microbiol, D-37077 Gottingen, Germany
关键词
Small RNA; noncoding RNA; Hfq; RNase E; sugar; polyadenylation;
D O I
10.1101/gad.1717808
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Noncoding RNA regulators have been implicated in almost all imaginable cellular processes. Here we review how regulatory small RNAs such as Spot42, SgrS, GlmY, and GlmZ and a cis-encoded ribozyme in glmS mRNA control sugar metabolism. Besides discussing the physiological implications, we show how the study of these molecules contributed to our understanding of the mechanisms and of general principles of RNA-based regulation. These include the post-transcriptional repression or activation of gene expression within polycistronic mRNAs; novel ribonucleoprotein complexes composed of small RNA, Hfq, and/or RNase E; and the hierarchical action of regulatory RNAs.
引用
收藏
页码:2914 / 2925
页数:12
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