A North American brain tumor consortium phase II study of poly-ICLC for adult patients with recurrent anaplastic gliomas

被引：64

作者：

Butowski, Nicholas ^{[1
]}

Lamborn, Kathleen R. ^{[1
]}

Lee, Bee L. ^{[2
]}

Prados, Michael D. ^{[1
]}

Cloughesy, Timothy ^{[3
]}

DeAngelis, Lisa M. ^{[4
]}

Abrey, Lauren ^{[4
]}

Fink, Karen ^{[5
]}

Lieberman, Frank ^{[6
]}

Mehta, Minesh ^{[7
]}

Robins, H. Ian ^{[7
]}

Junck, Larry ^{[8
]}

Salazar, Andres M. ^{[9
]}

Chang, Susan M. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA

[2] San Jose State Univ, San Jose, CA 95192 USA

[3] Univ Calif Los Angeles, Los Angeles, CA 90095 USA

[4] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[5] Baylor Univ, Dallas, TX 75246 USA

[6] Univ Pittsburgh Canc Pavil, Pittsburgh, PA 15232 USA

[7] Univ Wisconsin, Madison, WI 53792 USA

[8] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA

[9] Oncovir Inc, Washington, DC 20008 USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 2009年 / 91卷 / 02期

关键词：

Anaplastic glioma; Radiation therapy; Adjuvant therapy; Poly-ICLC; POLYINOSINIC-POLYCYTIDYLIC ACID; TOLL-LIKE RECEPTOR-3; L-LYSINE; ADJUVANT CHEMOTHERAPY; RADIATION-THERAPY; MALIGNANT GLIOMA; VINCRISTINE PCV; CANCER; CARBOXYMETHYLCELLULOSE; RADIOTHERAPY;

D O I：

10.1007/s11060-008-9705-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This phase II study was designed to determine the objective response rate and 6-month progression free survival of adult patients with recurrent supratentorial anaplastic glioma when treated with the immune modulator, polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (poly-ICLC). This was an open-labeled, single arm phase II study. Patients were treated with poly-ICLC alone. Patients may have had treatment for no more than two prior relapses. Treatment with poly-ICLC continued until tumor progression. Fifty five patients were enrolled in the study. Ten were ineligible after central review of pathology. Eleven percent of patients (5 of 45) had a radiographic response. Time to progression was known for 39 patients and 6 remain on treatment. The estimated 6-month progression free survival was 24%. The median survival time was 43 weeks. Poly-ICLC was well tolerated, but there was no improvement in 6-month progression free survival compared to historical database nor was there an encouraging objective radiographic response rate. Based on this study, poly-ICLC does not improve 6moPFS in patients with recurrent anaplastic gliomas but may be worth further study in combination with agents such as temozolomide.

引用

页码：183 / 189

页数：7

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