Quasispecies in viral persistence and pathogenesis of hepatitis C virus

被引：107

作者：

Forns, X ^{[1
]}

Purcell, RH ^{[1
]}

Bukh, J ^{[1
]}

机构：

[1] NIAID, Hepatitis Viruses Sect, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 10期

关键词：

D O I：

10.1016/S0966-842X(99)01590-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatitis C virus (HCV) is an important cause of chronic liver disease worldwide. This RNA virus circulates as a quasispecies and its genetic heterogeneity has been implicated in the lack of protective immunity against HCV and in its persistence following infection. HCV might escape from immune surveillance by developing mutations in proteins that are subject to immune pressure.

引用

页码：402 / 410

页数：9

共 78 条

[51] VIRAL PERSISTENCE [J].

OLDSTONE, MBA .

CELL, 1989, 56 (04) :517-520

[52] ANTIGENIC STRUCTURE OF HUMAN HEPATITIS-A VIRUS DEFINED BY ANALYSIS OF ESCAPE MUTANTS SELECTED AGAINST MURINE MONOCLONAL-ANTIBODIES [J].

PING, LH ;

LEMON, SM .

JOURNAL OF VIROLOGY, 1992, 66 (04) :2208-2216

[53] Evolution of hepatitis C virus quasispecies in hypervariable region 1 and the putative interferon sensitivity-determining region during interferon therapy and natural infection [J].

Polyak, SJ ;

McArdle, S ;

Liu, SL ;

Sullivan, DG ;

Chung, MJ ;

Hofgärtner, WT ;

Carithers, RL ;

McMahon, BJ ;

Mullins, JI ;

Corey, L ;

Gretch, DR .

JOURNAL OF VIROLOGY, 1998, 72 (05) :4288-4296

[54] Randomised trial of interferon α2b plus ribavirin for 48 weeks or for 24 weeks versus interferon α2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus [J].

Poynard, T ;

Marcellin, P ;

Lee, SS ;

Niederau, C ;

Minuk, GS ;

Ideo, G ;

Bain, V ;

Heathcote, J ;

Zeuzem, S ;

Trepo, C ;

Albrecht, J .

LANCET, 1998, 352 (9138) :1426-1432

[55] IMMUNITY IN HEPATITIS-C INFECTION [J].

PRINCE, AM ;

BROTMAN, B ;

HUIMA, T ;

PASCUAL, D ;

JAFFERY, M ;

INCHAUSPE, G .

JOURNAL OF INFECTIOUS DISEASES, 1992, 165 (03) :438-443

[56] Acute hepatitis C virus structural gene sequences as predictors of persistent viremia: Hypervariable region 1 as a decoy [J].

Ray, SC ;

Wang, YM ;

Laeyendecker, O ;

Ticehurst, JR ;

Villano, SA ;

Thomas, DL .

JOURNAL OF VIROLOGY, 1999, 73 (04) :2938-2946

[57] Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection [J].

Rehermann, B ;

Chang, KM ;

McHutchison, JG ;

Kokka, R ;

Houghton, M ;

Chisari, FV .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (06) :1432-1440

[58]

Rice C.M., 1996, FIELDS VIROLOGY, P931

[59] The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus [J].

Sáiz, JC ;

López-Labrador, FX ;

Ampurdanés, S ;

Dopazo, J ;

Forns, X ;

Sánchez-Tapias, JM ;

Rodés, J .

JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (04) :839-847

[60] MOLECULAR-BASIS OF VIRAL PERSISTENCE - A SINGLE AMINO-ACID CHANGE IN THE GLYCOPROTEIN OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS IS ASSOCIATED WITH SUPPRESSION OF THE ANTIVIRAL CYTOTOXIC LYMPHOCYTE-T RESPONSE AND ESTABLISHMENT OF PERSISTENCE [J].

SALVATO, M ;

BORROW, P ;

SHIMOMAYE, E ;

OLDSTONE, MBA .

JOURNAL OF VIROLOGY, 1991, 65 (04) :1863-1869

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