Quasispecies in viral persistence and pathogenesis of hepatitis C virus

被引：107

作者：

Forns, X ^{[1
]}

Purcell, RH ^{[1
]}

Bukh, J ^{[1
]}

机构：

[1] NIAID, Hepatitis Viruses Sect, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 10期

关键词：

D O I：

10.1016/S0966-842X(99)01590-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatitis C virus (HCV) is an important cause of chronic liver disease worldwide. This RNA virus circulates as a quasispecies and its genetic heterogeneity has been implicated in the lack of protective immunity against HCV and in its persistence following infection. HCV might escape from immune surveillance by developing mutations in proteins that are subject to immune pressure.

引用

页码：402 / 410

页数：9

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