Quasispecies in viral persistence and pathogenesis of hepatitis C virus

被引：107

作者：

Forns, X ^{[1
]}

Purcell, RH ^{[1
]}

Bukh, J ^{[1
]}

机构：

[1] NIAID, Hepatitis Viruses Sect, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 10期

关键词：

D O I：

10.1016/S0966-842X(99)01590-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatitis C virus (HCV) is an important cause of chronic liver disease worldwide. This RNA virus circulates as a quasispecies and its genetic heterogeneity has been implicated in the lack of protective immunity against HCV and in its persistence following infection. HCV might escape from immune surveillance by developing mutations in proteins that are subject to immune pressure.

引用

页码：402 / 410

页数：9

共 78 条

[71] VARIABLE AND HYPERVARIABLE DOMAINS ARE FOUND IN THE REGIONS OF HCV CORRESPONDING TO THE FLAVIVIRUS ENVELOPE AND NS1 PROTEINS AND THE PESTIVIRUS ENVELOPE GLYCOPROTEINS [J].

WEINER, AJ ;

BRAUER, MJ ;

ROSENBLATT, J ;

RICHMAN, KH ;

TUNG, J ;

CRAWFORD, K ;

BONINO, F ;

SARACCO, G ;

CHOO, QL ;

HOUGHTON, M ;

HAN, JH .

VIROLOGY, 1991, 180 (02) :842-848

[72] EVIDENCE FOR IMMUNE SELECTION OF HEPATITIS-C VIRUS (HCV) PUTATIVE ENVELOPE GLYCOPROTEIN VARIANTS - POTENTIAL ROLE IN CHRONIC HCV INFECTIONS [J].

WEINER, AJ ;

GEYSEN, HM ;

CHRISTOPHERSON, C ;

HALL, JE ;

MASON, TJ ;

SARACCO, G ;

BONINO, F ;

CRAWFORD, K ;

MARION, CD ;

CRAWFORD, KA ;

BRUNETTO, M ;

BARR, PJ ;

MIYAMURA, T ;

MCHUTCHINSON, J ;

HOUGHTON, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) :3468-3472

[73]

Wong DKH, 1998, J IMMUNOL, V160, P1479

[74] Immunity in chimpanzees chronically infected with hepatitis C virus: Role of minor quasispecies in reinfection [J].

Wyatt, CA ;

Andrus, L ;

Brotman, B ;

Huang, F ;

Lee, DH ;

Prince, AM .

JOURNAL OF VIROLOGY, 1998, 72 (03) :1725-1730

[75] FUNCTIONAL AND IMMUNOLOGICAL CHARACTERIZATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE GLYCOPROTEINS CONTAINING DELETIONS OF THE MAJOR VARIABLE REGIONS [J].

WYATT, R ;

SULLIVAN, N ;

THALI, M ;

REPKE, H ;

HO, D ;

ROBINSON, J ;

POSNER, M ;

SODROSKI, J .

JOURNAL OF VIROLOGY, 1993, 67 (08) :4557-4565

[76] Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo [J].

Yanagi, M ;

St Claire, M ;

Shapiro, M ;

Emerson, SU ;

Purcell, RH ;

Bukh, J .

VIROLOGY, 1998, 244 (01) :161-172

[77] Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee [J].

Yanagi, M ;

Purcell, RH ;

Emerson, SU ;

Bukh, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) :8738-8743

[78] Early antibody response against hypervariable region 1 is associated with acute self-limiting infections of hepatitis C virus [J].

Zibert, A ;

Meisel, H ;

Kraas, W ;

Schulz, A ;

Jung, G ;

Roggendorf, M .

HEPATOLOGY, 1997, 25 (05) :1245-1249

← 1 2 3 4 5 6 7 8 →