Dendritic cells in asthma

被引：70

作者：

van Helden, Mary J.

Lambrecht, Bart N. ^{[1
,2
]}

机构：

[1] Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium

[2] ErasmusMC, Dept Pulm Med, Rotterdam, Netherlands

来源：

CURRENT OPINION IN IMMUNOLOGY | 2013年 / 25卷 / 06期

基金：

欧洲研究理事会;

关键词：

HOUSE-DUST MITE; REGULATORY T-CELLS; ALLERGIC LUNG INFLAMMATION; ANTIGEN-PRESENTING CELLS; IN-VIVO; AIRWAY INFLAMMATION; LANGERHANS CELLS; INHALED ANTIGEN; TH2; RESPONSES; LYMPH-NODES;

D O I：

10.1016/j.coi.2013.10.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The lungs are constantly exposed to antigens, most of which are non-pathogenic and do not require the induction of an immune response. Dendritic cells (DCs) are situated at the basolateral site of the lungs and continuously scan the environment to detect the presence of pathogens and subsequently initiate an immune response. They are a heterogeneous population of antigen-presenting cells that exert specific functions. Compelling evidence is now provided that DCs are both sufficient and necessary to induce allergic responses against several inhaled harmless allergens. How various DC subsets exactly contribute to the induction of allergic asthma is currently a subject of intense investigation. We here review the current progress in this field.

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页码：745 / 754

页数：10

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