Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D

被引:801
作者
Matsuzaki, M
Misumi, O
Shin-I, T
Maruyama, S
Takahara, M
Miyagishima, SY
Mori, T
Nishida, K
Yagisawa, F
Nishida, K
Yoshida, Y
Nishimura, Y
Nakao, S
Kobayashi, T
Momoyama, Y
Higashiyama, T
Minoda, A
Sano, M
Nomoto, H
Oishi, K
Hayashi, H
Ohta, F
Nishizaka, S
Haga, S
Miura, S
Morishita, T
Kabeya, Y
Terasawa, K
Suzuki, Y
Ishii, Y
Asakawa, S
Takano, H
Ohta, N
Kuroiwa, H
Tanaka, K
Shimizu, N
Sugano, S
Sato, N
Nozaki, H
Ogasawara, N
Kohara, Y
Kuroiwa, T
机构
[1] Rikkyo St Pauls Univ, Coll Sci, Dept Life Sci, Toshima Ku, Tokyo 1718501, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Biomed Chem, Bunkyo Ku, Tokyo 1130033, Japan
[3] Natl Inst Genet, Ctr Genet Resource Informat, Shizuoka 4118540, Japan
[4] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan
[5] Natl Inst Livestock & Grassland Sci, Tsukuba, Ibaraki 3050901, Japan
[6] Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Bunkyo Ku, Tokyo 1130033, Japan
[7] Saitama Univ, Fac Sci, Dept Biochem & Mol Biol, Sakura Ku, Saitama 3388570, Japan
[8] Univ Tokyo, Inst Med Sci, Minato Ku, Tokyo 1088639, Japan
[9] Keio Univ, Sch Med, Dept Mol Biol, Shinjyuku Ku, Tokyo 1608582, Japan
[10] Kumamoto Univ, Grad Sch Sci & Technol, Dept Biol Sci, Kumamoto 8608555, Japan
[11] Nara Inst Sci & Technol, Grad Sch Biol Sci, Nara 6300101, Japan
关键词
D O I
10.1038/nature02398
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Small, compact genomes of ultrasmall unicellular algae provide information on the basic and essential genes that support the lives of photosynthetic eukaryotes, including higher plants(1,2). Here we report the 16,520,305-base-pair sequence of the 20 chromosomes of the unicellular red alga Cyanidioschyzon merolae 10D as the first complete algal genome. We identified 5,331 genes in total, of which at least 86.3% were expressed. Unique characteristics of this genomic structure include: a lack of introns in all but 26 genes; only three copies of ribosomal DNA units that maintain the nucleolus; and two dynamin genes that are involved only in the division of mitochondria and plastids. The conserved mosaic origin of Calvin cycle enzymes in this red alga and in green plants supports the hypothesis of the existence of single primary plastid endosymbiosis. The lack of a myosin gene, in addition to the unexpressed actin gene, suggests a simpler system of cytokinesis. These results indicate that the C. merolae genome provides a model system with a simple gene composition for studying the origin, evolution and fundamental mechanisms of eukaryotic cells.
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页码:653 / 657
页数:5
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