Functions and biosynthesis of plasmalogens in health and disease

被引：303

作者：

Brites, P

Waterham, HR

Wanders, RJA

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Clin Chem, Lab Genet Metab Dis, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Paediat, Lab Genet Metab Dis, NL-1105 AZ Amsterdam, Netherlands

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2004年 / 1636卷 / 2-3期

关键词：

plasmalogen; peroxisome; metabolic disorder;

D O I：

10.1016/j.bbalip.2003.12.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasmalogens (1-O-alk-1'-enyl-2-acyl glycerophospholipids) constitute a special class of phospholipids characterized by the presence of a vinyl-ether bond at the sn-1 position. Although long considered as biological peculiarities, interest in this group of phospholipids has grown in recent years, thanks to the realization that plasmalogens are involved in different human diseases. In this review, we summarize the current state of knowledge with respect to the enzymatic synthesis of plasmalogens, the characteristic topology of the enzymes involved and the biological roles that have been assigned to plasmalogens. (C) 2004 Elsevier B.V All rights reserved.

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页码：219 / 231

页数：13

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