Peripheral mononeuropathy induced by loose ligation of the sciatic nerve in the rat: Behavioral, electrophysiological and histopathologic studies

被引:13
作者
Bai, YH
Takemitsu, M
Atsuta, Y
Matsuno, T
机构
[1] Asahikawa Med Coll, Dept Orthopaed Surg, Asahikawa, Hokkaido 0788510, Japan
[2] Harbin Med Univ, Affiliated Hosp 2, Dept Orthopaed Surg, Harbin 150086, Peoples R China
关键词
electrophysiology; histopathology; hyperalgesia; peripheral mononeuropathy;
D O I
10.1538/expanim.48.87
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The relationship between clinical parameters and pathological changes was investigated in an animal model of mononeuropathy, by behavioral, electrophysiological and histopathological methods. Mononeuropathy was induced in rats by loosely tying ligatures around the sciatic nerve. Eighty-four rats were used, and these were divided into fourteen groups to determine chronological changes in the withdrawal reflex latency, nerve conduction velocity and ultrastructure of the nerve from 1 to 84 days after nerve ligation surgery. Pathological changes around the ligated nerves were divisible in three phases, the first week was an inflammatory phase, when axonal degeneration, phagocyte infiltration and interstitial edematous changes were observed. The second and third weeks were a nerve-sprouting phase, when numerous axonal sprouts and remyelination were seen. The fourth to twelfth weeks were a recovery phase in which maturing myelination and interstitial fibrosis were characteristic. In the inflammatory phase, withdrawal reflex latencies were shortened, and sensory nerve conduction velocities (SCV) and motor nerve conduction velocities (MCV) gradually decreased. In the nerve-sprouting phase, the latency values remained low, and SCV and MCV were minimal. The parameters examined gradually returned to control levels during the recovery phase. In conclusion, these findings increase the knowledge of disease progression in mononeuropathy with hyperalgesia in human and animal models.
引用
收藏
页码:87 / 94
页数:8
相关论文
共 18 条
[1]   FURTHER EVIDENCE FOR PAIN-RELATED BEHAVIORS IN A MODEL OF UNILATERAL PERIPHERAL MONONEUROPATHY [J].
ATTAL, N ;
JAZAT, F ;
KAYSER, V ;
GUILBAUD, G .
PAIN, 1990, 41 (02) :235-251
[2]   THE SPECTRUM OF FIBER LOSS IN A MODEL OF NEUROPATHIC PAIN IN THE RAT - AN ELECTRON-MICROSCOPIC STUDY [J].
BASBAUM, AI ;
GAUTRON, M ;
JAZAT, F ;
MAYES, M ;
GUILBAUD, G .
PAIN, 1991, 47 (03) :359-367
[3]   A PERIPHERAL MONONEUROPATHY IN RAT THAT PRODUCES DISORDERS OF PAIN SENSATION LIKE THOSE SEEN IN MAN [J].
BENNETT, GJ ;
XIE, YK .
PAIN, 1988, 33 (01) :87-107
[4]   NEUROMA FORMATION AND NUMBERS OF AXONS IN A RAT MODEL OF EXPERIMENTAL PERIPHERAL NEUROPATHY [J].
CARLTON, SM ;
DOUGHERTY, PM ;
POVER, CM ;
COGGESHALL, RE .
NEUROSCIENCE LETTERS, 1991, 131 (01) :88-92
[5]  
CUNHA Q, 1992, BRIT J PHARMACOL, V107, P660
[6]   NEURONAL RESPONSIVENESS IN THE VENTROBASAL THALAMIC COMPLEX OF RATS WITH AN EXPERIMENTAL PERIPHERAL MONONEUROPATHY [J].
GUILBAUD, G ;
BENOIST, JM ;
JAZAT, F ;
GAUTRON, M .
JOURNAL OF NEUROPHYSIOLOGY, 1990, 64 (05) :1537-1554
[7]   REPETITIVE STIMULATION-INDUCED POTENTIATION OF EXCITATORY TRANSMISSION IN THE RAT DORSAL HORN - AN IN-VITRO STUDY [J].
JEFTINIJA, S ;
URBAN, L .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 71 (01) :216-228
[8]   SPONTANEOUS DISCHARGE ORIGINATES IN THE DORSAL-ROOT GANGLION AT THE ONSET OF A PAINFUL PERIPHERAL NEUROPATHY IN THE RAT [J].
KAJANDER, KC ;
WAKISAKA, S ;
BENNETT, GJ .
NEUROSCIENCE LETTERS, 1992, 138 (02) :225-228
[9]   AN ELECTROPHYSIOLOGICAL STUDY OF DORSAL HORN NEURONS IN THE SPINAL-CORD OF RATS WITH AN EXPERIMENTAL PERIPHERAL NEUROPATHY [J].
LAIRD, JMA ;
BENNETT, GJ .
JOURNAL OF NEUROPHYSIOLOGY, 1993, 69 (06) :2072-2085
[10]  
LEVANTE A, 1989, EUR J NEUROSCI, P19