Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel

被引：444

作者：

Creutzig, Ursula ^{[1
]}

van den Heuvel-Eibrink, Marry M. ^{[2
]}

Gibson, Brenda ^{[3
]}

Dworzak, Michael N. ^{[4
,5
]}

Adachi, Souichi ^{[6
]}

de Bont, Eveline ^{[7
]}

Harbott, Jochen ^{[8
]}

Hasle, Henrik ^{[9
]}

Johnston, Donna ^{[10
]}

Kinoshita, Akitoshi ^{[11
]}

Lehrnbecher, Thomas ^{[12
]}

Leverger, Guy ^{[13
]}

Mejstrikova, Ester ^{[14
]}

Meshinchi, Soheil ^{[15
,16
]}

Pession, Andrea ^{[17
]}

Raimondi, Susana C. ^{[18
]}

Sung, Lillian ^{[19
]}

Stary, Jan ^{[20
,21
]}

Zwaan, Christian M. ^{[2
]}

Kaspers, Gertjan J. L. ^{[22
]}

Reinhardt, Dirk ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Pediat Hematol Oncol, D-30625 Hannover, Germany

[2] Erasmus MC Sophia Childrens Hosp, Dept Pediat Oncol Hematol, Rotterdam, Netherlands

[3] Royal Hosp Sick Children, Dept Haematol, Glasgow G3 8SJ, Lanark, Scotland

[4] Med Univ Vienna, Dept Pediat, St Anna Childrens Hosp, Vienna, Austria

[5] Med Univ Vienna, Dept Pediat, Childrens Canc Res Inst, Vienna, Austria

[6] Kyoto Univ, Grad Sch Med, Dept Human Hlth Sci, Kyoto, Japan

[7] Univ Groningen, Dept Pediat, Univ Med Ctr Groningen, Div Pediat Oncol Hematol, NL-9700 AB Groningen, Netherlands

[8] Univ Giessen, Oncogenet Lab, Dept Pediat Hematol & Oncol, Giessen, Germany

[9] Aarhus Univ, Hosp Skejby, Dept Pediat, Aarhus, Denmark

[10] Childrens Hosp Eastern Ontario, Div Hematol Oncol, Ottawa, ON K1H 8L1, Canada

[11] St Marianna Univ, Sch Med, Dept Pediat, Kawasaki, Kanagawa, Japan

[12] Goethe Univ Frankfurt, Frankfurt, Germany

[13] Univ Paris 07, Trousseau Hosp, AP HP, Dept Haemato Immuno Oncol, F-75221 Paris 05, France

[14] Charles Univ Prague, Sch Med 2, Dept Paediat Haematol & Oncol, Childhood Leukaemia Invest Prague, Prague, Czech Republic

[15] Univ Washington, Sch Med, Div Pediat Hematol Oncol, Seattle, WA USA

[16] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA

[17] Univ Bologna, Pediat Oncol & Hematol Lalla Seragnoli Unit, Bologna, Italy

[18] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

[19] Hosp Sick Children, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada

[20] Charles Univ Prague, Dept Pediat Hematol & Oncol, Prague, Czech Republic

[21] Czech Pediat Hematol Working Grp CPH, Prague, Czech Republic

[22] Vrije Univ Amsterdam, Med Ctr, Dept Pediat Oncol Hematol, Amsterdam, Netherlands

来源：

BLOOD | 2012年 / 120卷 / 16期

基金：

日本学术振兴会;

关键词：

ACUTE PROMYELOCYTIC LEUKEMIA; STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; ACUTE MYELOGENOUS LEUKEMIA; TRANS-RETINOIC ACID; INDEPENDENT PROGNOSTIC RELEVANCE; HIGH-DOSE CYTARABINE; MYELODYSPLASIA-RELATED CHANGES; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOBLASTIC-LEUKEMIA;

D O I：

10.1182/blood-2012-03-362608

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Despite major improvements in outcome over the past decades, acute myeloid leukemia (AML)remains a life-threatening malignancy in children, with current survival rates of similar to 70%. State-of-the-art recommendations in adult AML have recently been published in this journal by Dohner et al. The primary goal of an international expert panel of the International BFM Study Group AML Committee was to set standards for the management, diagnosis, response assessment, and treatment in childhood AML. This paper aims to discuss differences between childhood and adult AML, and to highlight recommendations that are specific to children. The particular relevance of new diagnostic and prognostic molecular markers in pediatric AML is presented. The general management of pediatric AML, the management of specific pediatric AML cohorts (such as infants)or subtypes of the disease occurring in children (such as Down syndrome related AML), as well as new therapeutic approaches, and the role of supportive care are discussed. (Blood. 2012;120(16):3187-3205)

引用

页码：3187 / 3205

页数：19

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