Total and regional gray matter volume is not related to APOE*E4 status in a community sample of middle-aged individuals

被引：44

作者：

Cherbuin, Nicolas ^{[1
]}

Anstey, Kaarin J. ^{[1
]}

Sachdev, Perminder S. ^{[2
,3
]}

Maller, Jerome J. ^{[4
]}

Meslin, Chantal ^{[1
]}

Mack, Holly A. ^{[1
]}

Wen, Wei ^{[2
,3
]}

Easteal, Simon ^{[5
]}

机构：

[1] Australian Natl Univ, Mental Hlth Res Ctr, Canberra, ACT 0200, Australia

[2] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia

[3] Prince Wales Hosp, Inst Neuropsychiat, Sydney, NSW, Australia

[4] Alfred & Monash Univ, Dept Psychol Med, Melbourne, Vic, Australia

[5] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2008年 / 63卷 / 05期

基金：

英国医学研究理事会;

关键词：

APOE; MRI; cerebral atrophy; voxel-based morphometry; hippocampus; amygdala;

D O I：

10.1093/gerona/63.5.501

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background. The APOE*E4 allele has been associated with greater gray matter atrophy and with Alzheimer's disease. The aim of this study was to investigate whether the relationship between cerebral gray matter atrophy and APOE*E4 genotype was also present in a community-dwelling, nondemented 60- to 64-year-old cohort. Methods. Hippocampal and amygdalar volumes were manually traced and analyzed on 331 cranial T1-weighted magnetic resonance imaging (MRI) scans to detect differences associated with APOE*E4 genotype. Voxel-based morphometric (VBM) analyses were applied to detect regional gray matter volume differences. Results. No total, hippocampal, or amygdalar gray matter volume difference was detected between APOE*E4 carriers and noncarriers. Conclusions. In nondemented 60- to 64-year-olds, there was no association between APOE genotype and gray matter volume using both region-of-interest analysis and VBM.

引用

页码：501 / 504

页数：4

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