Metabolic syndrome and periodontitis in Gullah African Americans with type 2 diabetes mellitus

Aim To assess associations of metabolic syndrome, and its individual components, with extent of severe periodontitis among patients with type 2 diabetes mellitus (T2DM). Materials & Methods We performed a secondary data analysis (N=283) using a cross-sectional study population of Gullah African Americans with T2DM. Extent of severe periodontitis was assessed as total diseased tooth-sites/person [evaluated as separate outcomes: 6+mm clinical attachment level (CAL), 5+mm periodontal probing depth (PPD)] using negative binomial regression techniques. Primary independent variables assessed in separate models included metabolic syndrome (yes/no), each metabolic syndrome component (low HDL, hypertension, high triglycerides, large waist circumference) and glycemic control (poor/good). Results Multivariable CAL-model results showed a significant association for metabolic syndrome status with extent of severe periodontitis (RR=2.77, p=0.03). The separate multivariable CAL-model including each metabolic syndrome component showed marginally increased rates among those with large waist circumference (RR=2.33, p=0.09) and those with HbA1c7% (RR=1.73, p=0.06). Multivariable PPD-models showed marginally increased rates among those with metabolic syndrome (RR=2.18, p=0.06). Conclusion Metabolic syndrome is associated with the extent of severe periodontitis in this Gullah population with T2DM.