Effect of lipid solubility on the development of chronic cross-tolerance between ethanol and different alcohols and barbiturates

被引：15

作者：

Khanna, JM ^{[1
]}

Le, AD ^{[1
]}

Kalant, H ^{[1
]}

Chau, A ^{[1
]}

Shah, G ^{[1
]}

机构：

[1] ADDICT RES FDN,TORONTO,ON M5S 2S1,CANADA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1997年 / 57卷 / 1-2期

关键词：

tolerance; chronic; cross-tolerance; alcohols; barbiturates; lipid solubility;

D O I：

10.1016/S0091-3057(96)00163-3

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Tolerance to ethanol and cross-tolerance to other alcohols (n-propanol, n-butanol, t-butanol, isobutanol, t-amyl alcohol, n-amyl alcohol, and benzyl alcohol) and barbiturates (pentobarbital, secobarbital, amobarbital, thiopental, barbital and phenobarbital) that differ in lipid:water partition coefficient was examined in rats after chronic pretreatment with ethanol. Tolerance and cross-tolerance were studied with three different measures (hypothermia, tilt-plane, and rotarod). Tolerance to ethanol resulted in significant cross-tolerance to alcohols with low lipid solubility (n-propanol and t-butanol), whereas no cross-tolerance was seen with alcohols of high lipid solubility (isobutanol, n-amyl alcohol, t-amyl alcohol and benzyl alcohol). Cross-tolerance to n-butanol (which has intermediate lipid solubility) appeared to be metabolic rather than functional. Tolerance to ethanol also resulted in significant cross-tolerance to barbital and phenobarbital, but not to pentobarbital, secobarbital, amobarbital or thiopental. These studies suggest that lipid solubility is an important factor in relation to specificity of cross-tolerance to alcohols and barbiturates. (C) 1997 Elsevier Science Inc.

引用

页码：101 / 110

页数：10

共 29 条

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