Photoactivatable carbon nanodots for cancer therapy

被引：42

作者：

Juzenas, Petras ^{[1
]}

Kleinauskas, Andrius ^{[1
]}

Luo, Pengju George ^{[2
,3
]}

Sun, Ya-Ping ^{[2
,3
]}

机构：

[1] Oslo Univ Hosp, Norwegian Radium Hosp, Inst Canc Res, Dept Radiat Biol, N-0310 Oslo, Norway

[2] Clemson Univ, Dept Chem, Clemson, SC 29634 USA

[3] Clemson Univ, Lab Emerging Mat & Technol, Clemson, SC 29634 USA

来源：

APPLIED PHYSICS LETTERS | 2013年 / 103卷 / 06期

基金：

美国国家科学基金会;

关键词：

HETEROGENEOUS PHOTOCATALYTIC OXIDATION; AQUEOUS-SOLUTIONS; QUANTUM DOTS; TIO2; CELL; SURVIVAL; OXYGEN; PHOTOSENSITIZERS; NANOPARTICLES; CYTOTOXICITY;

D O I：

10.1063/1.4817787

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

In this study, we describe a photocatalytic system based on spherical fluorescent carbon-core nanoparticles (nanodots) that can be activated with ultraviolet radiation. The carbon nanodots with a poly(propionylethylenimine-co-ethylenimine) coating were investigated in human prostate adenocarcinoma (Du145 and PC3) cell cultures in vitro. The cells become more sensitive to ultraviolet radiation when preincubated with the nanodots. The inverse slope of the cell survival curves is about 20-30% lower for the carbon nanodots and radiation compared to that for the radiation alone. Such photoactivatable carbon nanodots can be suggested for use in photocatalytic and photodynamic applications. (C) 2013 AIP Publishing LLC.

引用

页数：4

共 32 条

[1] Quantum dots as photosensitizers? [J].

Bakalova, R ;

Ohba, H ;

Zhelev, Z ;

Ishikawa, M ;

Baba, Y .

NATURE BIOTECHNOLOGY, 2004, 22 (11) :1360-1361

[2] Quantum dot anti-CD conjugates: Are they potential photosensitizers or potentiators of classical photosensitizing agents in photodynamic therapy of cancer? [J].

Bakalova, R ;

Ohba, H ;

Zhelev, Z ;

Nagase, T ;

Jose, R ;

Ishikawa, M ;

Baba, Y .

NANO LETTERS, 2004, 4 (09) :1567-1573

[3] CRITERIA AND TECHNIQUES FOR ANALYZING CELL-SURVIVAL DATA [J].

BETTEGA, D ;

CALZOLARI, P ;

OTTOLENGHI, A ;

LOMBARDI, LT .

RADIATION AND ENVIRONMENTAL BIOPHYSICS, 1991, 30 (01) :53-70

[4]

CAI RX, 1992, CANCER RES, V52, P2346

[5] Carbon dots for multiphoton bioimaging [J].

Cao, Li ;

Wang, Xin ;

Meziani, Mohammed J. ;

Lu, Fushen ;

Wang, Haifang ;

Luo, Pengju G. ;

Lin, Yi ;

Harruff, Barbara A. ;

Veca, L. Monica ;

Murray, Davoy ;

Xie, Su-Yuan ;

Sun, Ya-Ping .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (37) :11318-+

[6] Carbon Nanoparticles as Visible-Light Photocatalysts for Efficient CO2 Conversion and Beyond [J].

Cao, Li ;

Sahu, Sushant ;

Anilkumar, Parambath ;

Bunker, Christopher E. ;

Xu, Juan ;

Fernando, K. A. Shiral ;

Wang, Ping ;

Guliants, Elena A. ;

Tackett, Kenneth N., II ;

Sun, Ya-Ping .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (13) :4754-4757

[7] MEASUREMENTS ON DEPTH OF PENETRATION OF LIGHT (0.35-1.0MU-M) IN TISSUE [J].

EICHLER, J ;

KNOF, J ;

LENZ, H .

RADIATION AND ENVIRONMENTAL BIOPHYSICS, 1977, 14 (03) :239-242

[8] Photo induced hexylaminolevulinate destruction of rat bladder cells AY-27 [J].

Ekroll, Ingvild Kinn ;

Gederaas, Odrun Arna ;

Helander, Linda ;

Hjelde, Astrid ;

Melo, Thor Bernt ;

Johnsson, Anders .

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2011, 10 (06) :1072-1079

[9] HETEROGENEOUS PHOTOCATALYTIC OXIDATION OF CYANIDE ION IN AQUEOUS-SOLUTIONS AT TIO2 POWDER [J].

FRANK, SN ;

BARD, AJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (01) :303-304

[10] HETEROGENEOUS PHOTOCATALYTIC OXIDATION OF CYANIDE AND SULFITE IN AQUEOUS-SOLUTIONS AT SEMICONDUCTOR POWDERS [J].

FRANK, SN ;

BARD, AJ .

JOURNAL OF PHYSICAL CHEMISTRY, 1977, 81 (15) :1484-1488

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