Circulating plasma VEGF response to exercise in sedentary and endurance-trained men

被引:126
作者
Kraus, RM
Stallings, HW
Yeager, RC
Gavin, TP
机构
[1] E Carolina Univ, Human Performance Lab, Dept Exercise & Sport Sci, Greenville, NC 27858 USA
[2] E Carolina Univ, Human Performance Lab, Dept Physiol, Greenville, NC 27858 USA
关键词
vascular endothelial growth factor; soluble VEGF receptor; Flt-1; plasma; serum;
D O I
10.1152/japplphysiol.01031.2003
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The skeletal muscle capillary supply is an important determinant of maximum exercise capacity, and it is well known that endurance exercise training increases the muscle capillary supply. The muscle capillary supply and exercise-induced angiogenesis are regulated in part by vascular endothelial growth factor (VEGF). VEGF is produced by skeletal muscle cells and can be secreted into the circulation. We investigated whether there are differences in circulating plasma VEGF between sedentary individuals (Sed) and well-trained endurance athletes (ET) at rest or in response to acute exercise. Eight ET men (maximal oxygen consumption: 63.8 +/- 2.3 ml.kg(-1).min(-1); maximum power output: 409.4 +/- 13.3 W) and eight Sed men (maximal oxygen consumption: 36.3 +/- 2.1 ml.kg(-1).min(-1); maximum power output: 234.4 +/- 13.3 W) exercised for 1 h at 50% of maximum power output. Antecubital vein plasma was collected at rest and at 0, 2, and 4 h postexercise. Plasma VEGF was measured by ELISA analysis. Acute exercise significantly increased VEGF at 0 and 2 h postexercise in ET subjects but did not increase VEGF at any time point in Sed individuals. There was no difference in VEGF between ET and Sed subjects at any time point. When individual peak postexercise VEGF was analyzed, exercise did increase VEGF independent of training status. In conclusion, exercise can increase plasma VEGF in both ET athletes and Sed men; however, there is considerable variation in the individual time of the peak VEGF response.
引用
收藏
页码:1445 / 1450
页数:6
相关论文
共 38 条
[1]   Angiotensin II and VEGF are involved in angiogenesis induced by short-term exercise training [J].
Amaral, SL ;
Papanek, PE ;
Greene, AS .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (03) :H1163-H1169
[2]   CAPILLARY SUPPLY OF QUADRICEPS FEMORIS MUSCLE OF MAN - ADAPTIVE RESPONSE TO EXERCISE [J].
ANDERSEN, P ;
HENRIKSSON, J .
JOURNAL OF PHYSIOLOGY-LONDON, 1977, 270 (03) :677-&
[3]   Plasma levels of vascular endothelial growth factor and its soluble receptor (sFlt-1) in essential hypertension [J].
Belgore, FM ;
Blann, AD ;
Li-Saw-Hee, FL ;
Beevers, DG ;
Lip, GYH .
AMERICAN JOURNAL OF CARDIOLOGY, 2001, 87 (06) :805-+
[4]  
Benoy Ina, 2002, Clin Breast Cancer, V2, P311, DOI 10.3816/CBC.2002.n.008
[5]   PHYSICAL-FITNESS AND ALL-CAUSE MORTALITY - A PROSPECTIVE-STUDY OF HEALTHY-MEN AND WOMEN [J].
BLAIR, SN ;
KOHL, HW ;
PAFFENBARGER, RS ;
CLARK, DG ;
COOPER, KH ;
GIBBONS, LW .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1989, 262 (17) :2395-2401
[6]   Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of Fluvastatin or Fenofibrate [J].
Blann, AD ;
Belgore, FM ;
Constans, J ;
Conri, C ;
Lip, GYP .
AMERICAN JOURNAL OF CARDIOLOGY, 2001, 87 (10) :1160-1163
[7]   Vascular endothelial growth factor and its receptor, Flt-l, in the plasma of patients with coronary or peripheral atherosclerosis, or type II diabetes [J].
Blann, AD ;
Belgore, FM ;
McCollum, CN ;
Silverman, S ;
Lip, PL ;
Lip, GYH .
CLINICAL SCIENCE, 2002, 102 (02) :187-194
[8]  
BRODAL P, 1977, AM J PHYSIOL, V232, P705
[9]   Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele [J].
Carmeliet, P ;
Ferreira, V ;
Breier, G ;
Pollefeyt, S ;
Kieckens, L ;
Gertsenstein, M ;
Fahrig, M ;
Vandenhoeck, A ;
Harpal, K ;
Eberhardt, C ;
Declercq, C ;
Pawling, J ;
Moons, L ;
Collen, D ;
Risau, W ;
Nagy, A .
NATURE, 1996, 380 (6573) :435-439
[10]   Vascular endothelial growth factor and soluble P-selectin in acute and chronic congestive heart failure [J].
Chin, BSP ;
Chung, NAY ;
Gibbs, CR ;
Blann, AD ;
Lip, GYH .
AMERICAN JOURNAL OF CARDIOLOGY, 2002, 90 (11) :1258-+