Conditional gp130 deficient mouse mutants

被引:49
作者
Fasnacht, Nicolas [2 ]
Mueller, Werner [1 ,2 ]
机构
[1] Univ Manchester, Bill Ford Chair Cellular Immunol, Manchester M13 9PL, Lancs, England
[2] Helmholtz Ctr Infect Res, Braunschweig, Germany
关键词
gp130; Interleukin-6; Interleukin-11; Interleukin-27; Ciliary neurotropic factor; Leukemia inhibitory factor; Oncostatin M; Cardiotrophin-1; Cardiotrophin-like cytokine; Neuropoietin; Cre recombinase; Conditional mouse mutants;
D O I
10.1016/j.semcdb.2008.07.001
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The common cytokine receptor chain, gp130, controls the activity of a group of cytokines, namely, IL-6, IL-11, IL-27, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC) and neuropoietin (NPN). This family of cytokines is involved in multiple different biological processes, including inflammation, acute phase response, immune responses and cell survival. To analyze the different components of the gp130 network, mouse mutants for the single cytokine were generated by conventional gene targeting. However, since the cytokines of the IL-6 family show redundancy, it does not reveal the complete picture. Therefore, the study of mice with a cell type specific inactivation of the gp130 receptor chain is an approach that will subsequently allow the dissection of the cellular cytokine network. Here, we summarize the experimental results of the conditional gp130 mutants published so far. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:379 / 384
页数:6
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