The first selective antagonist for a GABA(C) receptor

被引：68

作者：

Murata, Y

Woodward, RM

Miledi, R

Overman, LE

机构：

[1] UNIV CALIF IRVINE,DEPT CHEM,IRVINE,CA 92697

[2] UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92697

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 17期

关键词：

D O I：

10.1016/0960-894X(96)00364-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(1,2,5,6-Tetrahydropyridine-4-yl)methylphosphinic acid (TPMPA, 1), which is synthesized in six steps from 3-butyn-1-ol, is the first gamma-aminobutyric acid (GABA) receptor antagonist that shows strong selectivity for mammalian GABA(C) receptors. Copyright (C) 1996 Elsevier Science Ltd

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页码：2073 / 2076

页数：4

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