Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes

被引：136

作者：

Cotter, PD

Emerson, N

Gahan, CGM

Hill, C ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Dept Microbiol, Cork, Ireland

[2] Natl Univ Ireland Univ Coll Cork, Natl Food Biotechnol Ctr, Cork, Ireland

来源：

JOURNAL OF BACTERIOLOGY | 1999年 / 181卷 / 21期

关键词：

D O I：

10.1128/JB.181.21.6840-6843.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

lisRK encodes a two-component regulatory system in the food pathogen Lister ia monocytogenes LO28. Following identification of the operon in an acid-tolerant Tn917 mutant, a deletion in the histidine kinase component was shown to result in a growth phase variation in acid tolerance, an ability to grow in high ethanol concentrations, and a significant reduction in virulence.

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页码：6840 / 6843

页数：4

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