Formal agent-based modelling of intracellular chemical interactions

被引：89

作者：

Pogson, Mark

Smallwood, Rod

Qwarnstrom, Eva

Holcombe, Mike ^{[1
]}

机构：

[1] Univ Sheffield, Dept Comp Sci, Computat Syst Biol Grp, Sheffield S10 2TN, S Yorkshire, England

[2] Univ Sheffield, Div Genom Med, Cell Biol Grp, Sheffield S10 2TN, S Yorkshire, England

来源：

BIOSYSTEMS | 2006年 / 85卷 / 01期

基金：

英国医学研究理事会; 英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

agent-based modelling; chemical interaction; nuclear factor kappa B; signalling pathway;

D O I：

10.1016/j.biosystems.2006.02.004

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Individual-based or agent-based models have proved useful in a variety of different biological contexts. This paper presents an agent-based model using a formal computational modelling approach to model a crucial biological system-the intracellular NF-kappa B signalling pathway. The pathway is vital to immune response regulation, and is fundamental to basic survival in a range of species. Alterations in pathway regulation underlie many diseases, including atherosclerosis and arthritis. Our modelling of individual molecules, receptors and genes provides a more comprehensive outline of regulatory network mechanisms than previously possible with equation-based approaches. The model has been validated with data obtained from single cell experimental analysis. (c) 2006 Published by Elsevier Ireland Ltd.

引用

页码：37 / 45

页数：9

共 21 条

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