Stereoselective synthesis of unsaturated very long chain fatty acid methyl esters

被引：7

作者：

Defretin, J ^{[1
]}

Saez, J ^{[1
]}

Franck, X ^{[1
]}

Hocquemiller, R ^{[1
]}

Figadère, B ^{[1
]}

机构：

[1] Univ Paris Sud, Fac Pharm, Assoc CNRS,BIOCIS, Lab Pharmacognoise, F-92296 Chatenay Malabry, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 21期

关键词：

acetogenins; olefins; lipids; Grignard reagents; transition metal catalysis;

D O I：

10.1016/S0040-4039(99)00666-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

:Very long chain fatty acids are isolated from many different natural sources. However their unsaturated and particularly their diunsaturated derivatives with a Delta(n,n+4) pattern are almost exclusively encountered in marine organisms, until we found some derivatives in the botanical family of the Annonaceae. In this letter we present a very efficient synthesis of this family of products based on the new transition metal-catalyzed coupling reaction between an organomagnesium reagent and a functionalized vinyl bromide. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4041 / 4044

页数：4

共 26 条

[1]

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