Regulation of lipid and lipoprotein metabolism by retinoids

被引：54

作者：

Staels, B

机构：

[1] Inst Pasteur, Dept Atherosclerose, INSERM, U 325, F-59019 Lille, France

[2] Univ Lille 2, Fac Pharm, Lille, France

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2001年 / 45卷 / 05期

关键词：

D O I：

10.1067/mjd.2001.113718

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Retinoids are small vitamin A-derived lipophilic compounds that influence a wide variety of developmental and metabolic processes. Retinoids exert their action by activating transcription factors belonging to the retinoic acid receptor (RAR) and retinoid X receptor (RXR) subfamilies of nuclear receptors. Therapeutically, retinoids are used for the treatment of dermatological disorders and certain cancers. Dyslipidemia is a common side-effect of therapy with the currently available retinoids. This review summarizes our current understanding of the molecular mechanisms of regulation of lipid and lipoprotein metabolism by retinoids.

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页码：S158 / S167

页数：10

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