Recent developments in protein kinase C inhibitors

被引：13

作者：

Harris, W ^{[1
]}

Wilkinson, SE ^{[1
]}

Nixon, JS ^{[1
]}

机构：

[1] ROCHE PROD LTD, RES CTR, WELWYN GARDEN CITY AL7 3AY, HERTS, ENGLAND

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 1997年 / 7卷 / 01期

关键词：

D O I：

10.1517/13543776.7.1.63

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The serine/threonine protein kinase isoenzyme family, protein kinase C (PKC), is a group of closely-related enzymes which apparently mediate a range of responses in different cell. types. Their involvement in cellular proliferation and differentiation has made inhibitors of these isoenzymes of great interest as potential anticancer agents. This review looks at compounds under investigation by a number of different pharmaceutical companies within the last two years and reports on their effectiveness in models of cell proliferation and multidrug-resistance.

引用

页码：63 / 68

页数：6

共 35 条

[1]

AKINAGA S, 1991, CANCER RES, V51, P4888

[2]

AKINGA S, 1993, CANCER CHEMOTH PHARM, V51, P183

[3]

BIRCHALL AM, 1994, J PHARMACOL EXP THER, V268, P922

[4] INHIBITORS OF PROTEIN-KINASE-C .3. POTENT AND HIGHLY SELECTIVE BISINDOLYLMALEIMIDES BY CONFORMATIONAL RESTRICTION [J].

BIT, RA ;

DAVIS, PD ;

ELLIOTT, LH ;

HARRIS, W ;

HILL, CH ;

KEECH, E ;

KUMAR, H ;

LAWTON, G ;

MAW, A ;

NIXON, JS ;

VESEY, DR ;

WADSWORTH, J ;

WILKINSON, SE .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (01) :21-29

[5] THERAPEUTIC POTENTIAL OF PROTEIN-KINASE-C INHIBITORS [J].

BRADSHAW, D ;

HILL, CH ;

NIXON, JS ;

WILKINSON, SE .

AGENTS AND ACTIONS, 1993, 38 (1-2) :135-147

[6]

BROKA CA, 1996, Patent No. 695755

[7]

CHIN JE, 1993, J BIOL CHEM, V268, P6338

[8] INHIBITORS OF PROTEIN-KINASE-C .2. SUBSTITUTED BISINDOLYMALEIMIDES WITH IMPROVED POTENCY AND SELECTIVITY [J].

DAVIS, PD ;

ELLIOTT, LH ;

HARRIS, W ;

HILL, CH ;

HURST, SA ;

KEECH, E ;

KUMAR, MKH ;

LAWTON, G ;

NIXON, JS ;

WILKINSON, SE .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (06) :994-1001

[9] INHIBITORS OF PROTEIN-KINASE-C .1. 2,3-BISARYLMALEIMIDES [J].

DAVIS, PD ;

HILL, CH ;

LAWTON, G ;

NIXON, JS ;

WILKINSON, SE ;

HURST, SA ;

KEECH, E ;

TURNER, SE .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (01) :177-184

[10]

Dean N, 1996, CANCER RES, V56, P3499

← 1 2 3 4 →