Animal models for respiratory chain disease

被引：39

作者：

Larsson, NG ^{[1
]}

Rustin, P

机构：

[1] Huddinge Hosp, Karolinska Inst, Novum, Dept Med Nutr, S-14186 Huddinge, Sweden

[2] Hop Necker Enfants Malad, INSERM, U393, Unite Rech Handicaps Genet Enfant, Paris, France

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 12期

关键词：

D O I：

10.1016/S1471-4914(01)02167-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Elucidation of the pathogenesis in respiratory chain diseases is of great importance for developing specific treatments. The limitations inherent to the use of patient material make studies of human tissues often difficult and the mouse has therefore emerged as a suitable model organism for studies of respiratory chain diseases. In this review, we present an overview of the field and discuss in depth a few examples of animal models reproducing pathology of human disease with primary and secondary respiratory chain involvement.

引用

页码：578 / 581

页数：4

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