The role of the podocyte in glomerulosclerosis

被引:135
作者
Kriz, W
Lemley, KV
机构
[1] Stanford Univ, Sch Med, Div Pediat Nephrol, Stanford, CA 94305 USA
[2] Heidelberg Univ, Inst Anat & Zellbiol, Heidelberg, Germany
关键词
D O I
10.1097/00041552-199907000-00014
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Focal segmental glomerulosclerosis is a pathological hallmark of many forms of progressive renal disease. The 'classic' lesion, based on the adhesion of the capillary tuft to Bowman's capsule, results from the loss of podocytes from the capillary basement membrane. The recently described 'collapsing' variant, in contrast, has an apparent excess of extracapillary cells, which may represent dedifferentiated, 'dysregulated' podocytes. Curr Opin Nephrol Hypertens 8:489-497. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:489 / 497
页数:9
相关论文
共 117 条
[1]  
Abbate M, 1998, J AM SOC NEPHROL, V9, P1213
[2]  
Anderson Sharon, 1995, P1553
[3]   Characterization of a B-2-bradykinin receptor in human glomerular podocytes [J].
Ardaillou, N ;
Blaise, V ;
Costenbader, K ;
Vassitch, Y ;
Ardaillou, R .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY, 1996, 271 (03) :F754-F761
[4]   Combined effects of an angiotensin converting enzyme inhibitor and a calcium antagonist on renal injury [J].
Bakris, GL ;
Griffin, KA ;
Picken, MM ;
Bidani, AK .
JOURNAL OF HYPERTENSION, 1997, 15 (10) :1181-1185
[5]   Podocytes undergo phenotypic changes and express macrophagic-associated markers in idiopathic collapsing glomerulopathy [J].
Bariéty, J ;
Nochy, D ;
Mandet, C ;
Jacquot, C ;
Glotz, D ;
Meyrier, A .
KIDNEY INTERNATIONAL, 1998, 53 (04) :918-925
[6]  
Barisoni L, 1999, J AM SOC NEPHROL, V10, P51
[7]   Assessment of the charge selectivity of glomerular basement membrane using Ficoll sulfate [J].
Bolton, GR ;
Deen, WM ;
Daniels, BS .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1998, 274 (05) :F889-F896
[8]  
BreitenederGeleff S, 1997, AM J PATHOL, V151, P1141
[9]   The role of proteinuria in the progression of chronic renal failure [J].
Burton, C ;
Harris, KPG .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1996, 27 (06) :765-775
[10]  
Chevalier Jacques, 1995, Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales, V189, P987