The role of the podocyte in glomerulosclerosis

被引：135

作者：

Kriz, W

Lemley, KV

机构：

[1] Stanford Univ, Sch Med, Div Pediat Nephrol, Stanford, CA 94305 USA

[2] Heidelberg Univ, Inst Anat & Zellbiol, Heidelberg, Germany

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 1999年 / 8卷 / 04期

关键词：

D O I：

10.1097/00041552-199907000-00014

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Focal segmental glomerulosclerosis is a pathological hallmark of many forms of progressive renal disease. The 'classic' lesion, based on the adhesion of the capillary tuft to Bowman's capsule, results from the loss of podocytes from the capillary basement membrane. The recently described 'collapsing' variant, in contrast, has an apparent excess of extracapillary cells, which may represent dedifferentiated, 'dysregulated' podocytes. Curr Opin Nephrol Hypertens 8:489-497. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：489 / 497

页数：9

共 117 条

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