Enantioselective H-atom transfer reactions:: A new methodology for the synthesis of β2-amino acids

被引：72

作者：

Sibi, MP ^{[1
]}

Patil, K ^{[1
]}

机构：

[1] N Dakota State Univ, Dept Chem, Fargo, ND 58105 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 10期

关键词：

amino acids; asymmetric catalysis; enantioselective H-atom transfer; Lewis acids; radical reactions;

D O I：

10.1002/anie.200353000

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A radical step: The addition of radicals to amino acrylates and subsequent H-atom transfer in the presence of chiral Lewis acid activators provides β2-amino acids in high yields and enantiomeric purity (see scheme; Ln* = chiral ligands, Fmoc = 9-fluorenylmethoxycarbonyl).

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页码：1235 / 1238

页数：4

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