The histone demethylase JMJD1A regulates adrenomedullin-mediated cell proliferation in hepatocellular carcinoma under hypoxia

被引：56

作者：

Park, Seong-Joon ^{[1
,2
]}

Kim, Joong-Gook ^{[1
]}

Son, Tae Gen ^{[1
]}

Yi, Joo Mi ^{[1
]}

Kim, Nam Deuk ^{[2
]}

Yang, Kwangmo ^{[1
,3
,4
]}

Heo, Kyu ^{[1
]}

机构：

[1] Dongnam Inst Radiol & Med Sci DIRAMS, Res Ctr, Pusan 619953, South Korea

[2] Pusan Natl Univ, Dept Pharm, Pusan 609735, South Korea

[3] Dongnam Inst Radiol & Med Sci, Dept Radiat Oncol, Pusan 619953, South Korea

[4] Korea Inst Radiol & Med Sci, Dept Radiat Oncol, Seoul, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2013年 / 434卷 / 04期

关键词：

Histone modification; Hypoxia; JMJD1A; ADM; Cell proliferation; POSSIBLE PROMOTION MECHANISM; CANCER-CELLS; TUMOR-GROWTH; IN-VIVO; EXPRESSION; TRANSCRIPTION; JHDM2A; HIF-1; LINES; ACTIVATION;

D O I：

10.1016/j.bbrc.2013.03.091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

We studied the roles of JMJD1A and its target gene ADM in the growth of hepatocellular carcinomas (HCCs) and breast cancer cells under hypoxic conditions. Hypoxia stimulated HepG2 and Hep3B cell proliferation but had no effect on MDA-MB-231 cell proliferation. Interestingly, the JMJD1A and ADM expressions were enhanced by hypoxia only in HepG2 and Hep3B cells. Our ChIP results showed that hypoxia-induced HepG2 and Hep3B cell proliferation is mediated by JMJD1A upregulation and subsequent decrease in methylation in the ADM promoter region. Furthermore, JMJD1A gene silencing abrogated the hypoxia-induced ADM expression and inhibited HepG2 and Hep3B cell growth. These data suggest that JMJD1A might function as a proliferation regulator in some cancer cell types. (c) 2013 Elsevier Inc. All rights reserved.

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页码：722 / 727

页数：6

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