Promoter structure of the MxA gene that confers resistance to influenza virus

被引：27

作者：

Nakade, K

Handa, H

Nagata, K

机构：

[1] Dept. of Biomolecular Engineering, Fac. of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama 226

[2] 2nd Pharmaceuticals Laboratory, Yokohama Research Center, Mitsubishi Chemical Corporation, Yokohama

来源：

FEBS LETTERS | 1997年 / 418卷 / 03期

关键词：

MxA; interferon; transcription promoter; influenza virus; reverse transcription-polymerase chain reaction; luciferase assay;

D O I：

10.1016/S0014-5793(97)01372-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human MxA protein is one of the interferon-inducible proteins that inhibits multiplication of influenza virus and other viruses. To clarify the control mechanism of its expression, we prepared a series of mutant MxA promoters and identified a 30 nucleotides long cis-acting interferon-responsive element by transient transfection assay. Its nucleotide sequence if somewhat similar to that of ISRE (interferon-stimulated response element), suggesting that the regulation of MxA mRNA synthesis is under the control of some ISRE binding factor such as ISGF-3 (interferon-stimulated gene factor-3).

引用

页码：315 / 318

页数：4

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