Centrosomal and non-centrosomal microtubules

被引:90
作者
Keating, TJ [1 ]
Borisy, GG [1 ]
机构
[1] Univ Wisconsin, Mol Biol Lab, Madison, WI 53706 USA
关键词
microtubule; minus ends; dynamics; non-centrosomal;
D O I
10.1016/S0248-4900(99)80093-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
While microtubule (MT) arrays in cells are often focused at the centrosome, a variety of cell types contain a substantial number of non-centrosomal MTs. Epithelial cells, neurons, and muscle cells all contain arrays of non-centrosomal MTs that are critical for these cells' specialized functions. There are several routes by which non-centrosomal MTs can arise, including release from the centrosome, cytoplasmic assembly, breakage or severing, and stabilization from non-centrosomal sites. Once formed, MTs that are not tethered to he centrosome must be organized, which can be accomplished by means of self-organization or by capture and nucleation of MTs where they are needed. The presence of free MTs requires stabilization of minus ends, either by MT-associated proteins or by an end-capping complex. Although some of the basic elements of free MT formation and organization are beginning to be understood, a great deal of work is still necessary before we have a complete picture of how non-centrosomal MT arrays are assembled in specific cell types. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:321 / 329
页数:9
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