Solvent-free synthesis of penta-substituted pyrroles: one-pot reaction of amine, alkyl acetoacetate, and furnaryl chloride

被引：29

作者：

Alizadeh, Abdolah ^{[1
]}

Babaki, Mohadese ^{[1
]}

Zohreh, Nasrin ^{[1
]}

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

TETRAHEDRON | 2009年 / 65卷 / 08期

关键词：

GRAM-POSITIVE BACTERIA; LAMELLARIN-O; DERIVATIVES; INHIBITORS; DIBENZOYLACETYLENE; BENZIMIDAZOLES; LUKIANOL; NINGALIN; ANALOGS; PAIRS;

D O I：

10.1016/j.tet.2008.12.011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, convenient, and efficient approach to the synthesis of penta-substituted pyrroles has been reported based on the multicomponent reaction. Solvent-free condition for the formation of enaminones from primary amines and alkyl acetoacetates and it's reaction with fumaryl chloride lead to the formation of pyrroles that have halide, CH2CO2H, ester functional groups, and two alkyl substitutions. (C) 2008 Elsevier Ltd. All rights reserved.

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收藏

页码：1704 / 1707

页数：4

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