Chronic morphine increases biosynthesis of nitric oxide synthase in the rat spinal cord

被引：63

作者：

Machelska, H ^{[1
]}

Ziolkowska, B ^{[1
]}

Mika, J ^{[1
]}

Przewlocka, B ^{[1
]}

Przewlocki, R ^{[1
]}

机构：

[1] POLISH ACAD SCI,INST PHARMACOL,DEPT MOL NEUROPHARMACOL,PL-31343 KRAKOW,POLAND

来源：

NEUROREPORT | 1997年 / 8卷 / 12期

关键词：

morphine tolerance; nitric oxide; nitric oxide synthase; nitric oxide synthase mRNA; nitric oxide synthase immunoreactivity; rat; spinal cord;

D O I：

10.1097/00001756-199708180-00020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE present study was undertaken to determine the influence of chronic morphine treatment on the biosynthesis of nitric oxide synthase (NOS) in the rat spinal cord using in situ hybridization and immunohistochemical methods. Repeated administration of morphine (20-100 mg/kg/day; 10 days) increased the NOS mRNA level in laminae I-IV and X 3 h after the last injection. That effect was accompanied by an increase in both the number of NOS-positive cells (24h) and the optical density of NOS-immunoreactivity (3 and 24h). The results indicate that repeated morphine administration increases NOS biosynthesis in the rat spinal cord, which may reflect adaptive changes accounting for development of opiate tolerance and dependence.

引用

页码：2743 / 2747

页数：5

共 25 条

[1] NITRIC-OXIDE AND OPIOID TOLERANCE [J].

BABEY, AM ;

KOLESNIKOV, Y ;

CHENG, J ;

INTURRISI, CE ;

TRIFILLETTI, RR ;

PASTERNAK, GW .

NEUROPHARMACOLOGY, 1994, 33 (11) :1463-1470

[2] NITRIC-OXIDE SYNTHASE ACTIVITY IN BRAIN-REGIONS AND SPINAL-CORD OF MICE AND RATS - KINETIC-ANALYSIS [J].

BARJAVEL, MJ ;

BHARGAVA, HN .

PHARMACOLOGY, 1995, 50 (03) :168-174

[3] EFFECT OF OPIOID RECEPTOR AGONISTS ON NITRIC-OXIDE SYNTHASE ACTIVITY IN RAT CEREBRAL-CORTEX HOMOGENATE [J].

BARJAVEL, MJ ;

BHARGAVA, HN .

NEUROSCIENCE LETTERS, 1994, 181 (1-2) :27-30

[4]

BARJAVEL MJ, 1994, SOC NEUR ABSTR, V20, P234

[5] CLONED AND EXPRESSED NITRIC-OXIDE SYNTHASE STRUCTURALLY RESEMBLES CYTOCHROME-P-450 REDUCTASE [J].

BREDT, DS ;

HWANG, PM ;

GLATT, CE ;

LOWENSTEIN, C ;

REED, RR ;

SNYDER, SH .

NATURE, 1991, 351 (6329) :714-718

[6] SPINAL NMDA RECEPTOR - NITRIC-OXIDE MEDIATION OF THE EXPRESSION OF MORPHINE-WITHDRAWAL SYMPTOMS IN THE RAT [J].

BUCCAFUSCO, JJ ;

TERRY, AV ;

SHUSTER, L .

BRAIN RESEARCH, 1995, 679 (02) :189-199

[7] SUSTAINED POTENTIATION OF NMDA RECEPTOR MEDIATED GLUTAMATE RESPONSES THROUGH ACTIVATION OF PROTEIN-KINASE-C BY A MU-OPIOID [J].

CHEN, L ;

HUANG, LYM .

NEURON, 1991, 7 (02) :319-326

[8] OPIOIDS CAN EVOKE DIRECT RECEPTOR-MEDIATED EXCITATORY EFFECTS ON SENSORY NEURONS [J].

CRAIN, SM ;

SHEN, KF .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (02) :77-81

[9] NITRIC-OXIDE SYNTHASE IMMUNOREACTIVITY IN THE RAT, MOUSE, CAT AND SQUIRREL-MONKEY SPINAL-CORD [J].

DUN, NJ ;

DUN, SL ;

WU, SY ;

FORSTERMANN, U ;

SCHMIDT, HHHW ;

TSENG, LF .

NEUROSCIENCE, 1993, 54 (04) :845-857

[10] Effect of spinal infusion of L-NAME, a nitric oxide synthase inhibitor, on spinal tolerance and dependence induced by chronic intrathecal morphine in the rat [J].

Dunbar, S ;

Yaksh, TL .

NEUROSCIENCE LETTERS, 1996, 207 (01) :33-36

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