In vivo sites and cellular mechanisms of T reg cell-mediated suppression

被引：92

作者：

Rudensky, AY

Campbell, DJ

机构：

[1] Univ Washington, Dept Immunol, Howard Hughes Med Inst, Seattle, WA 98195 USA

[2] Benaroya Res Inst, Seattle, WA 98101 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2006年 / 203卷 / 03期

关键词：

D O I：

10.1084/jem.20060214

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory CD4 T (T reg) cells control immune responses to self-antigens and pathogens. However, where T reg cells act to curtail effector T cells in vivo and what stage of effector T cell activation or differentiation is targeted by T reg cells remain unknown. Furthermore, a requirement for direct effector T cell-T reg cell contact in vivo has not been ascertained. Varying answers to these important questions have been provided by several new studies.

引用

收藏

页码：489 / 492

页数：4

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