Voltammetric determination of paracetamol at C60-modified glassy carbon electrode

Voltammetric determination of paracetamol was carried out at C-60-modified glassy carbon electrode, which showed stable response with enhanced selectivity and sensitivity. Limitations of conventional methods, viz., hydrolysis time and interference were also overstepped. Common biological and chemical interferents do not show significant interference in a wide concentration range. A linear calibration plot having correlation coefficient .985 was obtained in the range 0.05-1.5 mM paracetamol concentration and the sensitivity of the method has been found as 13.04 mu A mM(-1). Sweep rate studies indicated that electrode reaction is followed by follow-up chemical reactions. Method described is rapid and has been applied for the determination of paracetamol in different tablets and urine samples with several advantages over other analytical methods. The standard deviation (S.D.) was 5.53% for eight determinations. (c) 2005 Elsevier Ltd. All rights reserved.