Portacaval shunt control animals: Physiological consequences derived from the sham operation

被引：6

作者：

Lopez, L

Burgos, P

Santin, LJ

Begega, A

Arias, J

Lorente, L

Arias, JL

机构：

[1] UNIV OVIEDO,FAC PSYCHOL,PSYCHOBIOL LAB,OVIEDO 33005,SPAIN

[2] UNIV COMPLUTENSE MADRID,FAC MED,DEPT SURG,MADRID,SPAIN

来源：

LABORATORY ANIMALS | 1997年 / 31卷 / 03期

关键词：

portacaval shunt; hepatic encephalopathy; portosystemic encephalopathy; rat;

D O I：

10.1258/002367797780596239

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The portacaval shunt in the rat is a frequently used experimental model of portosystemic encephalopathy. Among other consequences of this surgical preparation is an important decrease in hepatic and testicular volume. Different sham-operation methods including a laparotomy were used as controls in each case. Given that the liver volume varies greatly in comparison to body weight in the sham-operated animals, this paper aims to evaluate the possible consequences of the sham operation. It concludes that control animals without manipulation, in addition to the respective controls of portacaval shunt, should be used in every case.

引用

页码：225 / 230

页数：6

共 19 条

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BLEI AT, 1992, NEUROMETHODS, V22, P183

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