Endogenous lung stem cells and contribution to disease

被引：65

作者：

Snyder, J. C. ^{[1
]}

Teisanu, R. M. ^{[1
]}

Stripp, B. R. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Pulm Allergy & Crit Care Med, Durham, NC 27710 USA

来源：

JOURNAL OF PATHOLOGY | 2009年 / 217卷 / 02期

关键词：

stem cells; lung; disease; neoplasia; OBSTRUCTIVE PULMONARY-DISEASE; HUMAN AIRWAY EPITHELIUM; PROTEIN-DEFICIENT MICE; ONCOGENIC K-RAS; KAPPA-B PATHWAY; CLARA CELL; BRONCHIOLAR EPITHELIUM; PROGENITOR CELLS; BASAL-CELLS; BETA-CELLS;

D O I：

10.1002/path.2473

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epithelial branching during the process of lung development results in the establishment of distinct functional zones, each of which is characterized by a unique cellular composition and repertoire of local progenitor cells. Significant new insights into cellular and molecular mechanisms of epithelial maintenance that provide insights into the pathophysiology of lung disease have been made in recent years. This review focuses on the complex structure-function relationship in the airway epithelium, how this epithelium is maintained in the normal state and repaired following injury, and how deregulation may contribute to airway disease and cancer. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：254 / 264

页数：11

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