Prediction of the response to chemoradiation and prognosis in oesophageal squamous cancer

被引:43
作者
Kishi, K [1 ]
Doki, Y [1 ]
Miyata, H [1 ]
Yano, M [1 ]
Yasuda, T [1 ]
Monden, M [1 ]
机构
[1] Osaka Univ, Grad Sch Med, Dept Surg & Clin Oncol, Osaka 5650871, Japan
关键词
D O I
10.1046/j.1365-2168.2002.02057.x
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: The sensitivity of cancer cells to chemotherapy and radiation therapy depends on various biological properties. This study investigated the expression of p53, CDC25B and metallothionein (MT), and evaluated their clinical significance in chemoradiation therapy (CRT) for oesophageal squamous cell carcinoma. Methods: The expression of p53, CDC25B and MT was evaluated by immunohistochemistry using biopsy specimens taken before CRT for 77 patients with oesophageal squamous cell carcinoma, and correlated with the pathological effects of CRT and survival. Results: p53-positive tumours and MT-positive tumours had a poor response to CRT, whereas tumours with strong CDC25B expression were associated with a good response. When each patient was scored for the presence of the three biological factors, there was a strong correlation between the sensitivity score and the pathological effect of CRT (P < 0.001), and a (non-significant) difference in the 5-year survival rate between patients with a high score and those with a low score (67 versus 34 per cent respectively; P = 0.12). Conclusions: The combined evaluation of p53, CDC25B and MT may help to identify patients with advanced oesophageal squamous cell carcinoma who will benefit from preoperative CRT.
引用
收藏
页码:597 / 603
页数:7
相关论文
共 40 条
[1]  
Bracey TS, 1997, CLIN CANCER RES, V3, P1371
[2]   A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage [J].
Brown, AL ;
Lee, CH ;
Schwarz, JK ;
Mitiku, N ;
Piwnica-Worms, H ;
Chung, JH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3745-3750
[3]   P53-DEPENDENT APOPTOSIS IN THE ABSENCE OF TRANSCRIPTIONAL ACTIVATION OF P53-TARGET GENES [J].
CAELLES, C ;
HELMBERG, A ;
KARIN, M .
NATURE, 1994, 370 (6486) :220-223
[4]  
EL DW, 1993, CELL, V75, P817
[5]   Pharmacological rescue of mutant p53 conformation and function [J].
Foster, BA ;
Coffey, HA ;
Morin, MJ ;
Rastinejad, F .
SCIENCE, 1999, 286 (5449) :2507-2510
[6]   SPECIFIC ACTIVATION OF CDC25 TYROSINE PHOSPHATASES BY B-TYPE CYCLINS - EVIDENCE FOR MULTIPLE ROLES OF MITOTIC CYCLINS [J].
GALAKTIONOV, K ;
BEACH, D .
CELL, 1991, 67 (06) :1181-1194
[7]   CDC25 PHOSPHATASES AS POTENTIAL HUMAN ONCOGENES [J].
GALAKTIONOV, K ;
LEE, AK ;
ECKSTEIN, J ;
DRAETTA, G ;
MECKLER, J ;
LODA, M ;
BEACH, D .
SCIENCE, 1995, 269 (5230) :1575-1577
[8]  
Gasparotto D, 1997, CANCER RES, V57, P2366
[9]   METALLOTHIONEIN [J].
HAMER, DH .
ANNUAL REVIEW OF BIOCHEMISTRY, 1986, 55 :913-951
[10]  
Hashimoto T, 1999, CANCER RES, V59, P5572