Mechanism of Alzheimer neurofibrillary degeneration and the formation of tangles

被引：18

作者：

Iqbal, K

GrundkeIqbal, I

机构：

[1] NYS Institute for Basic Research in Developmental Disabilities,

来源：

MOLECULAR PSYCHIATRY | 1997年 / 2卷 / 03期

关键词：

D O I：

10.1038/sj.mp.4000269

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The microtubule-associated protein (MAP) tau, which is abnormally hyperphosphorylated in the brain of patients with Alzheimer disease, sequesters normal MAPs and disassembles microtubules. The association between the abnormal tau and normal tau, and not MAP1 or MAP2, produces tangles of filaments. The breakdown of microtubule network most likely results in compromised axonal transport and retrograde degeneration of the affected neurons.

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页码：178 / 180

页数：3

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